Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus

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dc.contributor.authorItankar, Prakash R.en_US
dc.contributor.authorTauqeer, Mohammaden_US
dc.contributor.authorDalal, Jayshree S.en_US
dc.date.accessioned2020-11-18T10:11:55Z
dc.date.available2020-11-18T10:11:55Z
dc.date.issued2019-10
dc.description.abstractBackground: With the rapid depletion of forests, impairing the availability of raw drugs, Ayurveda, hasreached a very critical phase. Consequently, cultivation of medicinal plants is essential to ensure theiravailability to the industry. In view of the above concept, organic farming of medicinal plants needsscientific validity.Objectives: The present study includes the organic and non-organic cultivation of Cymbopogon citratus,followed by toxicological and pharmacological profiling of extracts.Materials and methods: C. citratus was simultaneously cultivated organically (OCC) and non-organically(NCC). Toxicity profile of aqueous extracts was recorded on prokaryotes using bioluminescent bacteria,Vibrio harveyi and evaluated its type 2 anti-diabetic activity.Results: OCC have shown the higher mean values of height, number of germplasms and root lengthscompared to NCC. The higher level of toxicity was shown by NCC with decrease in bioluminescence withincreasing concentration of extract. In acute type 2 anti-diabetic study, OCC showed prominent decreasein blood glucose at postprandial condition (6th h) (48.86% OCC-200). The order of sub-chronic antidiabetic activity was observed as positive control > OCC-200 > NCC-200, while OCC at 200 mg/kg corrected the altered lipid profile and antioxidant status with significant increase in body weights of animals. Histopathological examination of pancreas showed the enlargement of pancreatic islets andformation of neo islets with degenerative changes in OCC treated animals.Conclusion: The study confirms that organically grown C. citratus is better in terms of nourishment,biological activity and safety measures.© 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.identifier.affiliationsUniversity Department of Pharmaceutical Sciences, Department of Pharmacognosy and Phytochemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, Indiaen_US
dc.identifier.affiliationsUniversity Department of Pharmaceutical Sciences, Department of Pharmacognosy and Phytochemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, Indiaen_US
dc.identifier.affiliationsAgnihotri College of Pharmacy, Bapuji Wadi, Ramnagar, Wardha 442001, Maharashtra, Indiaen_US
dc.identifier.citationItankar Prakash R., Tauqeer Mohammad, Dalal Jayshree S.. Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus. Journal of Ayurveda and Integrative Medicine. 2019 Oct; 10(4): 233-240en_US
dc.identifier.issn0975-9476
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214086
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber4en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.1016/j.jaim.2017.04.002en_US
dc.subjectCymbopogon citratus Non-organic Organic Pharmacological Toxicologicalen_US
dc.titleToxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratusen_US
dc.typeJournal Articleen_US
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