Interleukin-6 in impaired fasting glucose

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dc.contributor.authorAgarwal, Ashishen_US
dc.contributor.authorHegde, Anupamaen_US
dc.contributor.authorYadav, Charuen_US
dc.contributor.authorAhmad, Afzalen_US
dc.contributor.authorManjrekar, Poornima Aen_US
dc.contributor.authorRukmini, MSen_US
dc.date.accessioned2020-01-02T06:23:11Z
dc.date.available2020-01-02T06:23:11Z
dc.date.issued2018-12
dc.description.abstractPrediabetes is associated with the features of metabolic syndrome and inflammation contributing directly to the pathogenesis of cardiovascular disease (CVD). This study was conducted to explore the utility of interleukin-6 (IL-6) in determining the risk of CVD in prediabetes. It involves estimation of IL-6 & insulin along with its correlation with insulin, fasting plasma glucose (FPG), Insulin resistance (IR) and physical measurements. Eighty subjects were grouped into 40 prediabetes and 40 normoglycemic on the basis of FPG values. The mean insulin, IL-6, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and anthropometric measurements were found to be significantly higher (P <0.05) in prediabetes group. IL-6 had a significant correlation with fasting insulin (r = −0.413) and HOMA-IR (r = −0.413), but no correlation with FPG (r = −0.227) in the prediabetes group. IL-6 also showed a positive correlation with body mass index BMI(r = −0.339), waist circumference WC (r = −484) and waist-to-hip ratio WHR (r = −0.430). This study concludes that prediabetes is associated with inflammation, increasing the risk of CVD in these individuals.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Kasturba Medical College, MAHE, Manipal University, Mangalore -575 004, Karnataka, Indiaen_US
dc.identifier.citationAgarwal Ashish, Hegde Anupama, Yadav Charu, Ahmad Afzal, Manjrekar Poornima A, Rukmini MS. Interleukin-6 in impaired fasting glucose. Indian Journal of Biochemistry and Biophysics. 2018 Dec; 55(12): 424-428en_US
dc.identifier.issn0975-0959
dc.identifier.issn0301-1208
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/190025
dc.languageenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.issuenumber5en_US
dc.relation.volume55en_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/45451en_US
dc.titleInterleukin-6 in impaired fasting glucoseen_US
dc.typeJournal Articleen_US
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