Staphylococcal scalded skin syndrome in neonate: Another face of CA-MRSA

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dc.contributor.authorRizwana, MMen_US
dc.contributor.authorShanmugapriya, Sen_US
dc.contributor.authorSudha, MJen_US
dc.contributor.authorAppalaraju, Ben_US
dc.contributor.authorRamesh, Sen_US
dc.date.accessioned2025-06-19T05:55:12Z
dc.date.available2025-06-19T05:55:12Z
dc.date.issued2025-03
dc.description.abstractStaphylococcal scalded skin syndrome (SSSS), also known as Ritter’s disease, in its severe form occurs predominantly in infants and children. It is caused by infection with group II (often phage group 71) Staphylococcus aureus. The foci of infection include nasopharynx, less commonly umbilicus, urinary tract, superficial abrasion, conjunctivae, and blood. Staphylococci are non?motile, non?spore?forming, catalase?positive, gram?positive cocci that appear predominantly as grape?like clusters. Although this organism is frequently a part of normal human microbial flora, it can cause significant opportunistic infections under certain conditions such as when extremes of age groups are involved, the presence of indwelling medical devices, and intravenous (iv) drug abuse. Staphylococcus aureus may cause a variety of infectious manifestations ranging from relatively benign skin infections to life?threatening systemic illnesses. SSSS caused by S. aureus strains produces exfoliative toxins which result in the development of blisters, erythema, and desquamation. Here, we present a case of an 11?day?old neonate who was diagnosed with SSSS. The causative agent responsible for this syndrome was identified as methicillin?resistant Staphylococcus aureus (MRSA). The molecular characterization of the gene Panton?Valentine leukocidin (PVL) was done by polymerase chain reaction (PCR) and was detected positive for PVL which is a distinctive virulence factor seen almost in all of the community?acquired MRSA strains. The patient was discharged after parenteral clindamycin therapy with almost complete resolution of symptoms.en_US
dc.identifier.affiliationsDepartments of Microbiologyen_US
dc.identifier.affiliationsDepartments of Microbiologyen_US
dc.identifier.affiliationsDepartments of Microbiologyen_US
dc.identifier.affiliationsDepartments of MicrobiologyPediatrics, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.citationRizwana MM, Shanmugapriya S, Sudha MJ, Appalaraju B, Ramesh S. Staphylococcal scalded skin syndrome in neonate: Another face of CA-MRSA. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 222-227en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249960
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_833_23en_US
dc.subjectBullaeen_US
dc.subjecterythemaen_US
dc.subjectinfanten_US
dc.subjectskin lesionsen_US
dc.subjecttoxinen_US
dc.titleStaphylococcal scalded skin syndrome in neonate: Another face of CA-MRSAen_US
dc.typeJournal Articleen_US
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