Effect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats.

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dc.contributor.authorDikshit, Men_US
dc.contributor.authorSrimal, R Cen_US
dc.date.accessioned1991-08-01en_US
dc.date.accessioned2009-05-27T08:30:13Z
dc.date.available1991-08-01en_US
dc.date.available2009-05-27T08:30:13Z
dc.date.issued1991-08-01en_US
dc.description.abstractEffect of lignocaine and centbucridine against isoproterenol-induced biochemical changes was studied in the rat. Isoproterenol (40 mg/kg twice) increased the heart weight, level of manolaldehyde (MDA) and activity of acid phosphatase, but decreased the myocardial phospholipid content at 48 h. In addition, increase in plasma triglyceride, cholesterol, MDA and creatine phosphokinase activity was observed. Pretreatment of the animals with lignocaine (10 mg/kg) or centbucridine (1, 3 and 10 mg/kg) protected the animals against these biochemical changes. However, increase in heart weight consequent to isoproterenol treatment could not be prevented. Total protection against creatine phosphokinase release in the blood was also not observed. The results suggest that the two drugs inhibit lipolysis. They may also inhibit phospholipases leading to protection against ischemia-induced changes in the rat.en_US
dc.description.affiliationDivision of Pharmacology, Central Drug Research Institute, Lucknow.en_US
dc.identifier.citationDikshit M, Srimal RC. Effect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats. Indian Journal of Medical Research. 1991 Aug; 94(): 307-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24675
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAcid Phosphatase --analysisen_US
dc.subject.meshAnesthetics, Local --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Disease --metabolismen_US
dc.subject.meshIsoproterenol --pharmacologyen_US
dc.subject.meshLidocaine --pharmacologyen_US
dc.subject.meshLipolysis --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshTacrine --analogs & derivativesen_US
dc.titleEffect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats.en_US
dc.typeJournal Articleen_US
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