Comparative study of the efficacy and safety of two grafting procedures (an automated epidermal harvesting system and non-cultured epidermal cell suspension) in the treatment of stable vitiligo

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dc.contributor.authorOberoi, Bhavnien_US
dc.contributor.authorBaveja, Sukritien_US
dc.contributor.authorPathania, Vikasen_US
dc.contributor.authorNeema, Shekharen_US
dc.date.accessioned2023-08-10T07:30:55Z
dc.date.available2023-08-10T07:30:55Z
dc.date.issued2023-08
dc.description.abstractBackground: The non-cultured epidermal cell suspension method is a well-established but tedious grafting modality in the management of stable vitiligo. Recently a more user-friendly automated epidermal harvesting system has been introduced. Aim: This was a pilot study to compare the efficacy and safety outcomes of the above two grafting procedures. Study design: The study was a single-blinded split-body randomised controlled trial. After scientific and ethical clearance, the trial was registered with CTRI (CTRI/2018/05/014225). Thirty consenting patients of stable vitiligo with 60 near-symmetrical patches were recruited. Block randomisation was done using computer-generated randomisation software and each patch was allocated either of the two grafting modalities. Efficacy was assessed by the Physician Global Assessment Scale on serial images and pain by the Numerical Rating Pain Scale. Results and conclusion: The non-cultured epidermal cell suspension was found to be an overall statistically superior technique to the automated epidermal harvesting system in terms of efficacy (re-pigmentation). Both donor and recipient site complications were significantly less with the automated epidermal harvesting system grafting and this method had the distinct advantage of being a painless and easy technique with minimal recovery time. A novel observation was that a good colour match and near-complete re-pigmentation occurred in patients with a darker skin colour with both techniques. Limitations: The main limitation of our study was the small sample size. Also, the size of the treated patches was limited such that they could be covered by the 5 × 5 cm size of the automated epidermal harvesting system blade. However, a larger area can be covered with multiple sessions.en_US
dc.identifier.affiliationsDepartment of Dermatology, INHS Asvini, Colaba, Mumbaien_US
dc.identifier.affiliationsDepartment of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.en_US
dc.identifier.citationOberoi, Bhavnien_US
dc.identifier.citationBaveja, Sukritien_US
dc.identifier.citationPathania, Vikasen_US
dc.identifier.citationNeema, Shekhar. Comparative study of the efficacy and safety of two grafting procedures (an automated epidermal harvesting system and non-cultured epidermal cell suspension) in the treatment of stable vitiligo. Indian Journal of Dermatology, Venereology and Leprology. 2023 Aug; 89(4): 536-542en_US
dc.identifier.issn0973-3922
dc.identifier.issn0378-6323
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223155
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber4en_US
dc.relation.volume89en_US
dc.source.urihttps://doi.org/10.25259/IJDVL_1010_2021en_US
dc.subjectVitiligoen_US
dc.subjectautomated epidermal harvesting systemen_US
dc.subjectnon-cultured epidermal cell suspensionen_US
dc.subjectgraftingen_US
dc.titleComparative study of the efficacy and safety of two grafting procedures (an automated epidermal harvesting system and non-cultured epidermal cell suspension) in the treatment of stable vitiligoen_US
dc.typeJournal Articleen_US
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