CD4/CD8 lymphocyte counts in healthy, HIV-positive individuals & AIDS patients.

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dc.contributor.authorRay, Krishnaen_US
dc.contributor.authorGupta, S Men_US
dc.contributor.authorBala, Manjuen_US
dc.contributor.authorMuralidhar, Sumathien_US
dc.contributor.authorKumar, Joginderen_US
dc.date.accessioned2006-09-07en_US
dc.date.accessioned2009-05-27T07:11:26Z
dc.date.available2006-09-07en_US
dc.date.available2009-05-27T07:11:26Z
dc.date.issued2006-09-07en_US
dc.description.abstractBACKGROUND & OBJECTIVES: The enumeration of CD4 and CD8 positive cells, surrogate markers for HIV disease progression, is helpful in management and follow up of immunocompromised HIV-positive patients. In assessing the degree of immune deficiency in HIV-positive patients of a particular region, knowledge of reference range of T-cell subset counts of healthy individuals of that particular region is essential. The present cross-sectional study was undertaken to determine the reference range of T-cell subsets in healthy north Indians and to compare the values with those in HIV-positives. METHODS: Blood samples from 125 HIV seronegative healthy volunteers comprising group I (88 males, 37 females) and 452 HIV- positive patients, divided into group II of asymptomatic (n=137; 93 males, 44 females) and group III of AIDS patients (n=315; 253 males, 62 females) in the age group of 17-60 yr, were analysed for enumeration of CD4+, CD8+ cells/microl by flow cytometry. RESULTS: In group I, the CD4 and CD8 levels were 687 +/- 219 and 611 +/- 288 cells/microl in males and 740 +/- 255 and 546 +/- 246 cells/microl in females. Overall, a significant depressed level of CD4 (525 +/- 207 cells/microl) and elevated level of CD8 (1174 +/- 484 cells/microl) in group II and (170 +/- 115 and 1051 +/- 586 cells/microl) respectively in group III were observed. Group II patients had highest level of CD8 cells. No asymptomatic women had CD4 count of <200 cells/microl. INTERPRETATION & CONCLUSION: Our findings on T-cell subset reference ranges of normal healthy north Indians validate the utility of determination of CD4 cell count as a useful predictor of AIDS in Indian conditions and confirm that a significant per cent of AIDS patients had CD4 cell count below 200/microl.en_US
dc.description.affiliationRegional STD Teaching Training and Research Centre, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India. drkray@yahoo.comen_US
dc.identifier.citationRay K, Gupta SM, Bala M, Muralidhar S, Kumar J. CD4/CD8 lymphocyte counts in healthy, HIV-positive individuals & AIDS patients. Indian Journal of Medical Research. 2006 Sep; 124(3): 319-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19679
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAcquired Immunodeficiency Syndrome --blooden_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCD4-CD8 Ratio --statistics & numerical dataen_US
dc.subject.meshCD4-Positive T-Lymphocytes --immunologyen_US
dc.subject.meshCD8-Positive T-Lymphocytes --immunologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHIV Infections --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.titleCD4/CD8 lymphocyte counts in healthy, HIV-positive individuals & AIDS patients.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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