Prognostic value of the Epstein–Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma

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dc.contributor.authorLiu, Junjieen_US
dc.contributor.authorLiu, Yingen_US
dc.contributor.authorZhang, Zhenyuen_US
dc.contributor.authorSun, Hongweien_US
dc.contributor.authorJi, Xiaofeien_US
dc.contributor.authorLi, Boqingen_US
dc.contributor.authorZhou, Xiuzhien_US
dc.contributor.authorGai, Pengzhouen_US
dc.date.accessioned2020-11-18T10:07:38Z
dc.date.available2020-11-18T10:07:38Z
dc.date.issued2019-04
dc.description.abstractAims and Methods: Retrospectively, this paper compared the differences of the Epstein–Barr virus (EBV)-encoded small RNAs (EBERs), protein expression and gene mutations of tumor suppressor gene p53 (TP53) in keratinized nasopharyngeal squamous cell carcinoma (KNSCC) and nonKNSCC, and the relationships between pathological features and the prognosis of patients were analyzed. Results: The positive rate of EBERs hybridization and TP53 expressions was 76.3% and 52.2%, respectively, while the mutation rate of TP53 gene was 39.6%. Logistic regression analysis showed direct relationships between the subtypes of nasopharyngeal squamous cell carcinoma (NPSCC) and EBERs-positive, or frequent consumption of pickled food. Overall survival rates of patients with positive TP53 expression, the TP53 gene mutations, vascular invasions, organ metastases, lymph node metastasis, and clinical recurrence were significantly lower than those of patients without those symptoms. The poorer prognosis was related to regularly drinking and the advanced age. According to the Cox regression analysis, we found that the main prognostic factors of NPSCC patients were the aging, recurrence, TP53 gene mutations, especially exon 7 or 8 mutations. Conclusions: We concluded that there were the correlations between NPSCC subtypes with EBV infection and frequent intaking of pickled food, while aging, clinical recurrence, and TP53 gene mutations were independent predictors for the poor prognosis of nasopharyngeal carcinomaen_US
dc.identifier.affiliationsDepartment of Basic Medical Sciences, School of Basic Medical Sciences, Binzhou Medical University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Medicine, Yantai Yuhuangding Hospital of Qingdao University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Medicine, Yantai Yuhuangding Hospital of Qingdao University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Public Health and Management, Binzhou Medical University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Basic Medical Sciences, School of Basic Medical Sciences, Binzhou Medical University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Basic Medical Sciences, School of Basic Medical Sciences, Binzhou Medical University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Basic Medical Sciences, School of Basic Medical Sciences, Binzhou Medical University, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Medicine, Yantai Yuhuangding Hospital of Qingdao University, Shandong, Chinaen_US
dc.identifier.citationLiu Junjie, Liu Ying, Zhang Zhenyu, Sun Hongwei, Ji Xiaofei, Li Boqing, Zhou Xiuzhi, Gai Pengzhou. Prognostic value of the Epstein–Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma. Journal of Cancer Research and Therapeutics. 2019 Apr; 15(2): 426-436en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213636
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_750_18en_US
dc.subjectEpstein–Barr virusen_US
dc.subjectgene mutationsen_US
dc.subjectnasopharyngeal squamous cell carcinomaen_US
dc.subjectprognosisen_US
dc.subjectprotein expressionsen_US
dc.subjecttumor suppressor gene p53en_US
dc.titlePrognostic value of the Epstein–Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinomaen_US
dc.typeJournal Articleen_US
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