Role of Vitamin B Complex as an Add-on Therapy to Diclofenac in Patients with Primary Osteoarthritis of the Knee

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dc.contributor.authorKaur, Jasmineen_US
dc.contributor.authorRani, Seemaen_US
dc.contributor.authorGulia, Anilen_US
dc.contributor.authorBhutani, Garimaen_US
dc.contributor.authorKumar, Sanjeeven_US
dc.contributor.authorNarwat, Arvinden_US
dc.date.accessioned2023-06-17T07:11:22Z
dc.date.available2023-06-17T07:11:22Z
dc.date.issued2021-06
dc.description.abstractObjective: This study was conducted with the aim to evaluate the efficacy and safety of Vitamin B complex as an add-on therapy to diclofenac in patients with primary osteoarthritis (OA) of the knee. Materials and Methods: In this prospective, open-labeled, randomized, and comparative clinical study, a total of 130 patients of age >40 years with primary OA of knee attending orthopedics OPD were randomly allocated into two groups of 65 each, i.e., Group D and Group B. In Group D, patients received tablet diclofenac 75 mg and in Group B, patients received tablet Vitamin B complex along with diclofenac once daily for 4 weeks, respectively. Clinical assessment was done at baseline and at the end of 4 weeks and 8 weeks by the visual analog scale (VAS), WOMAC index, and Lequesne index. Results: During the intergroup comparison, it was found that Vitamin B complex as an add-on therapy to diclofenac produced statistically significant reduction in mean VAS pain score (P < 0.05). However, the difference in mean WOMAC index and Lequesne index was not statistically different at 4 and 8 weeks between the two groups (P > 0.05). Mild side effects were seen at 4 weeks, but no side effects persisted up to 8 weeks in both the groups. Conclusion: The present study suggested that Vitamin B complex as an add-on therapy was found to cause a significant reduction in pain score. It could be a promising drug in patients with OA to improve the analgesic effect, when combined can reduce the dose of diclofenac, thereby minimizing the side effects.en_US
dc.identifier.affiliationsDepartments of Pharmacology and Orthopedics, BPS Government Medical College for Women, Khanpur, Kalan, Sonipat, Haryana, Indiaen_US
dc.identifier.citationKaur Jasmine,Rani Seema,Gulia Anil,Bhutani Garima,Kumar Sanjeev,Narwat Arvind. Role of Vitamin B Complex as an Add-on Therapy to Diclofenac in Patients with Primary Osteoarthritis of the Knee. Journal of Pharmacology and Pharmacotherapeutics. 2021 Jun; 12(2): 68–72en_US
dc.identifier.issn0976-500X
dc.identifier.issn0976-5018
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216010
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.4103/jpp.jpp_32_21en_US
dc.subjectKnee osteoarthritisen_US
dc.subjectLequesne indexen_US
dc.subjectvisual analog scaleen_US
dc.subjectVitamin B complexen_US
dc.subjectWOMAC indexen_US
dc.titleRole of Vitamin B Complex as an Add-on Therapy to Diclofenac in Patients with Primary Osteoarthritis of the Kneeen_US
dc.typeJournal Articleen_US
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