Value of DOPEG estimation in CSF in depression.

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dc.contributor.authorJohri, M Sen_US
dc.contributor.authorMisra, N Pen_US
dc.contributor.authorGaur, K Jen_US
dc.contributor.authorTrivedi, H Hen_US
dc.date.accessioned1990-12-01en_US
dc.date.accessioned2009-05-27T06:42:07Z
dc.date.available1990-12-01en_US
dc.date.available2009-05-27T06:42:07Z
dc.date.issued1990-12-01en_US
dc.description.abstract3,4-Dihydroxyphenyl ethylene glycol (DOPEG), a metabolite of noradrenaline (NA), was estimated in CSF of 30 patients of depression diagnosed by the criteria of American Psychiatric Association in DSM-III; and compared with levels in 10 non-depressed individuals who served as controls. Mean DOPEG levels in CSF in the patient group (801.37 +/- 28.09 micrograms/l) were significantly higher (P less than 0.01) than those in the control group (724.3 +/- 34.62 micrograms/l). Formation of excessive amount of this particular metabolite suggests an excessive intraneuronal deamination of NA, partially accounting for the overall decline in the availability of NA in the noradrenergic neurons in patients of depression.en_US
dc.description.affiliationDepartment of Medicine, Government Medical College, Jabalpur.en_US
dc.identifier.citationJohri MS, Misra NP, Gaur KJ, Trivedi HH. Value of DOPEG estimation in CSF in depression. Indian Journal of Medical Research. 1990 Dec; 92(): 417-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17516
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshDepression --cerebrospinal fluiden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMethoxyhydroxyphenylglycol --analogs & derivativesen_US
dc.subject.meshNorepinephrine --metabolismen_US
dc.titleValue of DOPEG estimation in CSF in depression.en_US
dc.typeJournal Articleen_US
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