Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases.

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dc.contributor.authorKhar, Aen_US
dc.contributor.authorAli, A Men_US
dc.contributor.authorBegum, Zen_US
dc.contributor.authorPardhasaradhi, B Ven_US
dc.contributor.authorVaralakshmi, Cen_US
dc.date.accessioned1999-04-05en_US
dc.date.accessioned2009-05-27T09:48:53Z
dc.date.available1999-04-05en_US
dc.date.available2009-05-27T09:48:53Z
dc.date.issued1999-04-05en_US
dc.description.abstractAK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis. DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells.en_US
dc.description.affiliationCentre for Cellular and Molecular Biology, Hyderabad, India. khar@ccmb.ap.nic.inen_US
dc.identifier.citationKhar A, Ali AM, Begum Z, Pardhasaradhi BV, Varalakshmi C. Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases. Indian Journal of Biochemistry & Biophysics. 1999 Apr; 36(2): 77-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28640
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis --drug effectsen_US
dc.subject.meshCaspases --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshRotenone --pharmacologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleInduction of apoptosis in AK-5 cells by rotenone involves participation of caspases.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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