A comparative study of letrozole and clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome: a randomized controlled trial

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dc.contributor.authorIlangovan, Subashreeen_US
dc.date.accessioned2024-09-24T09:09:27Z
dc.date.available2024-09-24T09:09:27Z
dc.date.issued2024-08
dc.description.abstractBackground: Effective ovulation induction is crucial in management of polycystic ovarian syndrome (PCOS) related infertility. Clomiphene citrate (CC) has long been the first line of treatment for inducing ovulation in women with PCOS. Letrozole, an aromatase inhibitor, has emerged as a promising alternative to CC for ovulation induction. The present study was aimed to compare efficacy and safety of letrozole versus CC for ovulation induction in women with PCOS.Methods: This study consists of 384 PCOS women, randomized into two groups: Letrozole (2.5 mg/day) and CC (50 mg/day), both administered from day 3 to day 7 of the menstrual cycle. The primary outcome was the ovulation rate, confirmed by serum progesterone levels >10 ng/ml. Secondary outcomes included clinical pregnancy rate, live birth rate, endometrial thickness, adverse effects, cost-effectiveness, and patient satisfaction. Participants were monitored through transvaginal ultrasound and serum progesterone measurements.Results: Ovulation was achieved in 76.0% of participants in the letrozole group compared to 55.2% in the CC group (p<0.001). Clinical pregnancy rates were significantly higher in the letrozole group (44.8%) compared to the CC group (28.1%) (p<0.001). Similarly, live birth rates were higher with letrozole (36.5% vs. 22.4%; p=0.002). Endometrial thickness was greater in the letrozole group (8.7 mm vs. 7.5 mm; p<0.001). Adverse effects, were significantly lower in the letrozole group.Conclusions: Letrozole is more effective than CC in inducing ovulation and achieving higher pregnancy and live birth rates in women with PCOS.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Sri Venkateshwara Medical College Hospital and Research Institute, Red Hills, Thiruvallur, Tamil Nadu, Indiaen_US
dc.identifier.citationIlangovan Subashree. A comparative study of letrozole and clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome: a randomized controlled trial . International Journal of Reproduction, Contraception, Obstetrics and Gynecology . 2024 Aug; 13(8): 1999-2003en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/232810
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2320-1770.ijrcog20241954en_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectLetrozoleen_US
dc.subjectCCen_US
dc.subjectOvulation inductionen_US
dc.subjectInfertilityen_US
dc.titleA comparative study of letrozole and clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome: a randomized controlled trialen_US
dc.typeJournal Articleen_US
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