An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital

Simple item page
dc.contributor.authorV, Ken_US
dc.contributor.authorK, Men_US
dc.contributor.authorS, Den_US
dc.contributor.authorG, C.en_US
dc.date.accessioned2023-06-27T06:39:37Z
dc.date.available2023-06-27T06:39:37Z
dc.date.issued2022-12
dc.description.abstractBackground: Drug-drug interactions are quite prevalent, especially in the geriatric population with comorbidities. It affects the effectiveness, safety, and tolerability of the medications they use. Aims and Objectives: This study aims to analyze and identify potential drug-drug interactions (pDDIs) in hypertensive patients using Medscape databases. Materials and Methods: A prospective and observational study was conducted in the Hypertension clinic of KMC, Chennai, for 3 months during November 2019–January 2020. Hypertensive patients of both sexes attending hypertension clinics with an age of more than 18 years and taking more than two antihypertensive drugs were included in the study. The use of Medscape databases enabled the appropriate data to be gathered and evaluated for pDDIs. Results: Three hundred patients in all were enrolled for the trial. One hundred and forty out of the 300 patients had pDDIs. Out of 140 patients, the majority (55%) were between the ages of 40 and 60. Males (56.4%) had a higher prevalence of pDDIs than females (43.6%). Atenolol, enalapril, and furosemide were the most frequently used medications in the present study that caused pDDIs, accounting for 29.8%, 19.5%, and 18.6%, respectively. Conclusion: The prevalence of pDDIs was found to be 46.6% overall, and an increase in comorbidities and polypharmacy were revealed to be important risk factors for the emergence of several pDDIs. Most of the antihypertensives were shown to interact frequently with calcium carbonate.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Salem Medical College, Salem, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Pudukkottai Medical College, Pudukkottai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsInstitute of Pharmacology, Madras Medical College, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationV K, K M, S D, G C.. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Dec; 12(12): 2184-2189en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217855
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber12en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.11511202207112022en_US
dc.subjectPotential Drug-drug Interactions-pDDIsen_US
dc.subjectHypertensionen_US
dc.subjectMedscape Databasesen_US
dc.titleAn observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
NJPPP2022v12n12p2184.pdf
Size:
772.85 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology