Comparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trial

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dc.contributor.authorMorya, Arvind Kumaren_US
dc.contributor.authorGurnani, Bharaten_US
dc.contributor.authorMishra, Deepaken_US
dc.contributor.authorKaur, Kirandeepen_US
dc.contributor.authorPorwal, Amiten_US
dc.contributor.authorSisodia, Priyaen_US
dc.contributor.authorTejaswini, Antarvedien_US
dc.contributor.authorBalakrishnan, Logeshen_US
dc.date.accessioned2023-08-25T06:35:10Z
dc.date.available2023-08-25T06:35:10Z
dc.date.issued2022-11
dc.description.abstractPurpose: The purpose of this study was to compare and analyze the endothelial cell loss during manual small-incision cataract surgery (MSICS) using the viscoelastic-assisted nucleus removal versus basal salt solution plus technique. Methods: This was a prospective randomized trial of 204 patients who underwent MSICS using viscoelastic-assisted nucleus removal (Group 1- OVD) versus basal salt solution plus technique (Group 2- BSS) at a tertiary eye care hospital in North India from January 2018 to 2021. Of these 204 patients, 103 (50.5%) and 101 (49.5%) were allocated to Group 1 and 2, respectively. The parameters assessed were detailed history, demographics, and anterior and posterior segment details. Visual acuity, intraocular pressure (IOP), keratometry, pachymetry, and endothelial cell density were evaluated preoperatively and postoperatively on day 1 and 30. Results: The mean age of the patients was 64.5 � 8.2 years (range 48� years). There were 129 (63.2%) males and 75 (36.8%) females. The mean LogMAR visual acuity for both groups on day 1 (Group 1- 0.3 � 0.1, Group 2- 0.5 � 0.2) and day 30 (Group 1- 0.1 � 0.2, Group 2- 0.1 � 0.1) was statistically significant (P < 0.001), and the mean IOP value showed a statistically significant value (P < 0.009) on day 1 in Group 2 (15.0 � 2.4 mmHg) and on day 30 (P < 0.001) in both the groups (Group 1- 13.6 � 1.8 mmHg, Group 2- 13.5 � 2 mmHg). The horizontal and vertical k values also showed a statistically significant difference on day 1 and day 30 (P < 0.001). The mean percentage change of central corneal thickness (CCT) in Group 1 was 17.7% and in Group 2 was 17.4% on day 1, and it was 1.1% on day 30 in both the groups, which was statistically significant (P < 0.001) compared to preoperative values. The percentage change in endothelial cell density on day 1 was 9% in Group 1 and 4.6% in Group 2, which was statistically significant (P < 0.001). On day 30, it was 9.7% and 4.8%, respectively, which was statistically significant (P < 0.001). Conclusion: Our study highlights statistically significant endothelial cell loss with viscoelastic-assisted nuclear delivery compared to BSS-assisted nuclear delivery during MSICS in a short follow-up of 1 month. The CCT values showed a slight increase, and the keratometry and IOP were unaffected compared to the preoperative parameters in both the groupsen_US
dc.identifier.affiliationsDepartment of Ophthalmology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsCataract, Cornea, Trauma, Ocular Surface, External Diseases, Uvea and Refractive Services, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsRegional Institute of Ophthalmology, Banaras Hindu University, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsCataract, Pediatric Ophthalmology and Strabismus Services, Om Parkash Eye Institute, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsGlaucoma Services, Choitram Netralaya, Indore, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsCornea and Refractive Services, Sri Satguru Seva Sung Trust, Janki Kund, Chitrakoot, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsBiostatician, Aravind Eye Hospital, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.citationMorya Arvind Kumar, Gurnani Bharat, Mishra Deepak, Kaur Kirandeep, Porwal Amit, Sisodia Priya, Tejaswini Antarvedi, Balakrishnan Logesh. Comparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trial. Indian Journal of Ophthalmology. 2022 Nov; 70(11): 3960-3966en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224682
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber11en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1871_22en_US
dc.subjectBalanced salt solutionen_US
dc.subjectendothelial cell counten_US
dc.subjectmanual small-incision cataract surgery (MSICS)en_US
dc.subjectnucleus extractionen_US
dc.subjectviscoelasticen_US
dc.titleComparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trialen_US
dc.typeJournal Articleen_US
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