Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development in Drosophila melanogaster

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dc.contributor.authorChatterjee, Arunitaen_US
dc.contributor.authorKumar, Aavulaen_US
dc.contributor.authorNongthomba, Upendraen_US
dc.date.accessioned2020-11-18T10:20:51Z
dc.date.available2020-11-18T10:20:51Z
dc.date.issued2019-11
dc.description.abstractHaematopoiesis is a complex process in which the regulatory mechanisms of several implicated transcription factors remain uncertain. Drosophila melanogaster is an excellent model to resolve the unanswered questions about the blood cell development. This study describes the role of Beadex, a Drosophila homologue of LIM domain only 2 (LMO2), in haematopoiesis. Mutants of Beadex were analysed for blood cell abnormalities. Crystal cells, a subset of haemocytes, were significantly more in Beadex hypermorphic flies. Similarly, Beadex misexpression in prohemocytes altered the crystal cell numbers. Stage-specific misexpression analyses demonstrated that Beadex functions after the prohemocytes enter the crystal cell lineage. We also discovered that Pannier–U-shaped complex is a negative regulator of the crystal cell differentiation and is possibly negatively regulated by Beadex through its interaction with Pannier. We, therefore, suggest the mechanism of two novel regulators of crystal cell specification—Beadex and Pannier—during Drosophila haematopoiesis.en_US
dc.identifier.affiliationsDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru 560 012, Indiaen_US
dc.identifier.citationChatterjee Arunita, Kumar Aavula, Nongthomba Upendra. Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development in Drosophila melanogaster. Journal of Genetics. 2019 Nov; 98: 1-7en_US
dc.identifier.issn0022-1333
dc.identifier.issn0973-7731
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215462
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.volume98en_US
dc.source.urihttps://doi.org/10.1007/s12041-019-1154-6en_US
dc.subjecthaematopoiesisen_US
dc.subjectDrosophilaen_US
dc.subjectBeadexen_US
dc.subjectpannieren_US
dc.subjectcrystal cellen_US
dc.subjectLIM domain only.en_US
dc.titleBeadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development in Drosophila melanogasteren_US
dc.typeJournal Articleen_US
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