Plasma level of diethylcarbamazine in jirds and hamsters.
dc.contributor.author | Kimura, E | en_US |
dc.contributor.author | Aoki, Y | en_US |
dc.contributor.author | Nakajima, Y | en_US |
dc.contributor.author | Niwa, M | en_US |
dc.date.accessioned | 2009-05-27T16:38:46Z | |
dc.date.available | 2009-05-27T16:38:46Z | |
dc.date.issued | 1984-03-01 | en_US |
dc.description | The Southeast Asian Journal of Tropical Medicine and Public Health. | en_US |
dc.description.abstract | The relation between the dosage and plasma level of diethylcarbamazine (DEC) in jirds and hamsters was examined by gas-liquid chromatography. When the drug was given intraperitoneally to jirds at 100 mg/kg body weight, the plasma level rose rapidly and reached the maximum level (20-25 micrograms/ml) at 10 minutes and afterwards fell quickly to undetectable level at 4 hours. Even if larger dosage (300 mg/kg) was given, DEC was eliminated completely from the blood circulation within 8 hours. When the same dosages of DEC were given intraperitoneally, the DEC levels remained 2-4 hours longer in the blood of hamsters than in the blood of jirds. DEC given by stomach intubation at 100 mg/kg remained detectable much longer in hamsters (8 hrs) than in jirds (2 hrs). A repeated doses schedule did not show a tendency for the drug to accumulate. DEC was excreted in the urine and feces, but the total amount of drug excreted without metabolic changes was only about 8% of the given dosage. The majority of unmetabolized DEC was excreted in the urine within 0-12 hours. | en_US |
dc.identifier.citation | Kimura E, Aoki Y, Nakajima Y, Niwa M. Plasma level of diethylcarbamazine in jirds and hamsters. The Southeast Asian Journal of Tropical Medicine and Public Health. 1984 Mar; 15(1): 74-9 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/35688 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.tm.mahidol.ac.th/seameo/publication.htm | en_US |
dc.subject.mesh | Administration, Oral | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cricetinae | en_US |
dc.subject.mesh | Diethylcarbamazine --administration & dosage | en_US |
dc.subject.mesh | Feces --analysis | en_US |
dc.subject.mesh | Gerbillinae | en_US |
dc.subject.mesh | Injections, Intraperitoneal | en_US |
dc.title | Plasma level of diethylcarbamazine in jirds and hamsters. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
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