Plasma level of diethylcarbamazine in jirds and hamsters.

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dc.contributor.authorKimura, Een_US
dc.contributor.authorAoki, Yen_US
dc.contributor.authorNakajima, Yen_US
dc.contributor.authorNiwa, Men_US
dc.date.accessioned2009-05-27T16:38:46Z
dc.date.available2009-05-27T16:38:46Z
dc.date.issued1984-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe relation between the dosage and plasma level of diethylcarbamazine (DEC) in jirds and hamsters was examined by gas-liquid chromatography. When the drug was given intraperitoneally to jirds at 100 mg/kg body weight, the plasma level rose rapidly and reached the maximum level (20-25 micrograms/ml) at 10 minutes and afterwards fell quickly to undetectable level at 4 hours. Even if larger dosage (300 mg/kg) was given, DEC was eliminated completely from the blood circulation within 8 hours. When the same dosages of DEC were given intraperitoneally, the DEC levels remained 2-4 hours longer in the blood of hamsters than in the blood of jirds. DEC given by stomach intubation at 100 mg/kg remained detectable much longer in hamsters (8 hrs) than in jirds (2 hrs). A repeated doses schedule did not show a tendency for the drug to accumulate. DEC was excreted in the urine and feces, but the total amount of drug excreted without metabolic changes was only about 8% of the given dosage. The majority of unmetabolized DEC was excreted in the urine within 0-12 hours.en_US
dc.identifier.citationKimura E, Aoki Y, Nakajima Y, Niwa M. Plasma level of diethylcarbamazine in jirds and hamsters. The Southeast Asian Journal of Tropical Medicine and Public Health. 1984 Mar; 15(1): 74-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35688
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiethylcarbamazine --administration & dosageen_US
dc.subject.meshFeces --analysisen_US
dc.subject.meshGerbillinaeen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.titlePlasma level of diethylcarbamazine in jirds and hamsters.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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