Mutations in the S gene region of hepatitis B virus genotype D in Turkish patients.

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dc.contributor.authorOzaslan, Mehmeten_US
dc.contributor.authorOzaslan, Ersanen_US
dc.contributor.authorBarsgan, Arzuen_US
dc.contributor.authorKoruk, Mehmeten_US
dc.date.accessioned2007-12-29en_US
dc.date.accessioned2009-06-02T07:16:35Z
dc.date.available2007-12-29en_US
dc.date.available2009-06-02T07:16:35Z
dc.date.issued2007-12-29en_US
dc.description.abstractThe S gene region of the hepatitis B virus (HBV) is responsible for the expression of surface antigens and includes the 'a'-determinant region. Thus, mutation(s) in this region would afford HBV variants a distinct survival advantage, permitting the mutant virus to escape from the immune system. The aim of this study was to search for mutations of the S gene region in different patient groups infected with genotype D variants of HBV, and to analyse the biological significance of these mutations. Moreover, we investigated S gene mutation inductance among family members. Forty HBV-DNA-positive patients were determined among 132 hepatitis B surface antigen (HbsAg) carriers by the first stage of seminested PCR. Genotypes and subtypes were established by sequencing of the amplified S gene regions. Variants were compared with original sequences of these serotypes, and mutations were identified. All variants were designated as genotype D and subtype ayw3. Ten kinds of point mutations were identified within the S region. The highest rates of mutation were found in chronic hepatitis patients and their family members. The amino acid mutations 125 (M -> T) and 127 (T -> P) were found on the first loop of 'a'-determinant. The other consequence was mutation inductance in a family member. We found some mutations in the S gene region known to be stable and observed that some of these mutations affected S gene expression.en_US
dc.description.affiliationDepartment of Biology, University of Gaziantep, 27310 Gaziantep, Turkey. ozaslansmd@yahoo.comen_US
dc.identifier.citationOzaslan M, Ozaslan E, Barsgan A, Koruk M. Mutations in the S gene region of hepatitis B virus genotype D in Turkish patients. Journal of Genetics. 2007 Dec; 86(3): 195-201en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/114339
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jgenet/index.htmlen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshDNA, Viral --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Viralen_US
dc.subject.meshHepatitis B --transmissionen_US
dc.subject.meshHepatitis B Surface Antigens --geneticsen_US
dc.subject.meshHepatitis B virus --classificationen_US
dc.subject.meshHumansen_US
dc.subject.meshInfectious Disease Transmission, Verticalen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutationen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshTurkeyen_US
dc.titleMutations in the S gene region of hepatitis B virus genotype D in Turkish patients.en_US
dc.typeJournal Articleen_US
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