Advancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients.

Simple item page
dc.contributor.authorOvartlarnporn, Mudjalinen_US
dc.contributor.authorJongjaroenprasert, Wallayaen_US
dc.date.accessioned2009-05-27T19:28:32Z
dc.date.available2009-05-27T19:28:32Z
dc.date.issued2007-03-13en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThere have been case reports about adverse effects to glucose homeostasis related to gatifloxacin use. The authors report an elderly, non-diabetic patient who developed severe hyperglycemia after receiving oral gatifloxacin 400mg/d. He was a 73-year-old male, patient with a history of hypertension, cured vesical pheochromocytoma, idiopathic dilated cardiomyopathy, chronic renal insufficiency (baseline serum creatinine of 1.7 mg/dL), and gouty arthritis admitted to the hospital with a diagnosis of acute bronchitis. Seven days after initiating gatifloxacin, his symptoms were improved. Subsequently he developed polyuria, polydipsia, and fatigue with an increase in serum creatinine to 2.8 mg/dL, and random plasma glucose levels elevated to 903 mg/dL. Gatifloxacin was stopped. Intravenous regular insulin infusion was administered. Euglycemia was achieved within 8 hours after fluid rehydration and only low dose insulin was required He maintained normal glucose levels without any antidiabetic drugs afterward. Old age and renal impairment were considered significant contributing factors for this hyperglycemic adverse event from gatifloxacin.en_US
dc.description.affiliationEndocrine Unit, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Rama 6 Rd, Rajathevi, Bangkok 10400, Thailand.en_US
dc.identifier.citationOvartlarnporn M, Jongjaroenprasert W. Advancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients. Journal of the Medical Association of Thailand. 2007 Mar; 90(3): 569-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41199
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Infective Agents --adverse effectsen_US
dc.subject.meshFluoroquinolones --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperglycemia --chemically induceden_US
dc.subject.meshKidney Failure, Chronic --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.titleAdvancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand