Levamisole and mebendazole in the treatment of bancroftian infection.

Simple item page
dc.contributor.authorNarasimham, M Ven_US
dc.contributor.authorRoychowdhury, S Pen_US
dc.contributor.authorDas, Men_US
dc.contributor.authorRao, C Ken_US
dc.date.accessioned2009-05-27T15:19:58Z
dc.date.available2009-05-27T15:19:58Z
dc.date.issued1978-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractLevamisole and mebendazole, broad spectrum anthelminthic compounds were tested against microfilaria of Wuchereria bancrofti, and the results were compared with similarly treated diethylcarbamazine and untreated group. Levamisole at a dosage of 3 mg/kg daily for 8 days showed marked reduction in both microfilaria rate and microfilaria density and immediately thereafter mf-rate steadily increased almost up to pre-treatment level, the mf-density however showed only marginal increase. Mebendazole at dosage of 6 mg/kg daily for 10 days following 8 days treatment of levamisole also showed marginal increase of mf-rate but no increase of mf-density. Treatment with DEC at a dosage of 6 mg/kg daily for 12 days showed comparatively better results both in respect of reduction in mf-rate and mf-density. The reactions - severity and duration were more among levamisole treated groups as compared to DEC treated group. Thus with the dosages tried, DEC could be considered as a better drug than levamisole and mebendazole. Both the latter compounds had no or very limited effect on the adult worms of W. bancrofti.en_US
dc.identifier.citationNarasimham MV, Roychowdhury SP, Das M, Rao CK. Levamisole and mebendazole in the treatment of bancroftian infection. The Southeast Asian Journal of Tropical Medicine and Public Health. 1978 Dec; 9(4): 571-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32515
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBenzimidazoles --therapeutic useen_US
dc.subject.meshDiethylcarbamazine --therapeutic useen_US
dc.subject.meshFilariasis --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshLevamisole --adverse effectsen_US
dc.subject.meshMebendazole --therapeutic useen_US
dc.subject.meshPlacebosen_US
dc.subject.meshWuchereria bancroftien_US
dc.titleLevamisole and mebendazole in the treatment of bancroftian infection.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health