Biochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger.

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dc.contributor.authorPal, Samar Kumaren_US
dc.contributor.authorDas, Tapan Kumaren_US
dc.date.accessioned2005-12-03en_US
dc.date.accessioned2009-06-01T14:51:21Z
dc.date.available2005-12-03en_US
dc.date.available2009-06-01T14:51:21Z
dc.date.issued2005-12-03en_US
dc.description.abstractTwo cadmium resistant mutants (Cd1 and Cd2) of Aspergillus niger, among the six isolated by mutagenization with N-methyl N'-nitro-N-nitrosoguanidine (MNNG) at pH 6.4 were selected for the study. Analysis of lipid composition of the mutants and the wildtype indicated that total lipid as well as individual lipids of the cadmium resistant mutants were changed as compared with that of the wildtype. The increased activities of metal-lothionein and reduced activities of D-xylose isomerase and L-phenylalanine ammonia lyase in cell free extract of the cadmium resistant mutants suggested that mutants could allow high concentration of cadmium salt as compared with that of the wildtype. The respiratory activity and intracellular as well as extracellular Cd2+ concentration of the mutants reflected the high tolerance of the Cd mutants to cadmium ion.en_US
dc.description.affiliationDepartment of Biochemistry and Biophysics, University of Kalyani, Nadia 741 235, India.en_US
dc.identifier.citationPal SK, Das TK. Biochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger. Journal of Biosciences. 2005 Dec; 30(5): 639-46en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111126
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAldose-Ketose Isomerases --analysisen_US
dc.subject.meshAspergillus niger --chemistryen_US
dc.subject.meshCadmium --analysisen_US
dc.subject.meshDNA Mutational Analysisen_US
dc.subject.meshDrug Resistance, Fungal --geneticsen_US
dc.subject.meshLipids --chemistryen_US
dc.subject.meshMetallothionein --analysisen_US
dc.subject.meshMethylnitronitrosoguanidine --toxicityen_US
dc.subject.meshMutagenesis --geneticsen_US
dc.subject.meshMycelium --chemistryen_US
dc.subject.meshOxygen Consumption --geneticsen_US
dc.subject.meshPhenylalanine Ammonia-Lyase --analysisen_US
dc.subject.meshSurvival Analysisen_US
dc.titleBiochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger.en_US
dc.typeJournal Articleen_US
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