Intrapatient variability in plasma rifampicin & isoniazid in tuberculosis patients

Simple item page
dc.contributor.authorKumar, AKen_US
dc.contributor.authorChandrasekaran, Ven_US
dc.contributor.authorKannan, Ten_US
dc.contributor.authorLavanya, Jen_US
dc.contributor.authorSwaminathan, Sen_US
dc.contributor.authorRamachandran, Gen_US
dc.date.accessioned2020-04-10T01:37:53Z
dc.date.available2020-04-10T01:37:53Z
dc.date.issued2018-03
dc.description.abstractBackground & objectives: Large variability in anti-tuberculosis (TB) drug concentrations between patients is known to exist. However, limited information is available on intrapatient drug levels during the course of anti-TB treatment (ATT). This study was conducted to evaluate intrapatient variability in plasma rifampicin (RMP) and isoniazid (INH) concentrations during ATT at start of the treatment, at the end of intensive phase (IP) of ATT and at the end of ATT in adult TB patients being treated in the Revised National TB Control Programme (RNTCP). Methods: Adult TB patients (n=485), receiving thrice-weekly ATT in the RNTCP, were studied. Two-hour post-dosing concentrations of RMP and INH were determined at month 1, end of IP and end of ATT, after directly observed drug administration. Drug concentrations were estimated by high-performance liquid chromatography. Results: The median (inter-quartile range) RMP concentrations during the first month, at end of IP and end of ATT were 2.1 (0.4-5.0), 2.4 (0.6-5.5) and 2.2 (0.5-5.3) ?g/ml, respectively. The corresponding INH concentrations were 7.1 (4.2-9.9), 7.2 (3.9-10.9) and 6.7 (3.9-9.5) ?g/ml. None of the differences in drug concentrations obtained at different time points during ATT were significant. RMP and INH concentrations at different time points were significantly correlated. Age and body mass index caused significant variability in drug concentrations. Interpretation & conclusions: Plasma RMP and INH estimations in adult TB patients at two hours after drug administration remained unaltered during ATT. Clinicians can consider testing drug concentrations at any time point during ATT. These findings may assume significance in the context of therapeutic drug monitoring of anti-TB drug concentrations.en_US
dc.identifier.affiliationsDepartment of Biochemistry & Clinical Pharmacology; ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, Indiaen_US
dc.identifier.affiliationsDistrict TB Officer, Chennai Corporation, Chennai, Indiaen_US
dc.identifier.affiliationsICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, Indiaen_US
dc.identifier.citationKumar AK, Chandrasekaran V, Kannan T, Lavanya J, Swaminathan S, Ramachandran G. Intrapatient variability in plasma rifampicin & isoniazid in tuberculosis patients. Indian Journal of Medical Research. 2018 Mar; 147(3): 287-292en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195481
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber3en_US
dc.relation.volume147en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_1961_16en_US
dc.subjectIntrapatient variabilityen_US
dc.subjectisoniaziden_US
dc.subjectplasma drug concentrationsen_US
dc.subjectRevised National TB Control Programmeen_US
dc.subjectrifampicinen_US
dc.subjecttuberculosisen_US
dc.titleIntrapatient variability in plasma rifampicin & isoniazid in tuberculosis patientsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2018v147n3p287.pdf
Size:
412.09 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Medical Research