Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt.

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dc.contributor.authorAmin, Maha Mohamed
dc.contributor.authorAzim, Zeinab Abdel
dc.date.accessioned2012-10-16T04:39:43Z
dc.date.available2012-10-16T04:39:43Z
dc.date.issued2012-01
dc.description.abstractBackground and Objective: Psoriasis is a chronic inflammatory skin disease characterized by hyper-proliferation, abnormal differentiation, and inflammatory infiltration in epidermis and dermis. We planned this study to analyze probable associations between Osteopontin (OPN), Ki-67, CD34, and histopathological features in psoriasis. Materials and Methods: We studied OPN expression and its correlation with Ki-67 and CD34 expression in lesional, non-lesional skin, and normal skin. Immunoreactivity for OPN and Ki-67 was based on the level of epidermal staining. CD34 expression was scored as mild, moderate, and strong, according to the number of stained dermal capillaries. Results: Our results showed statistically significant differences in the expression of OPN, Ki-67, and CD34 between lesional and non-lesional skin as well as between non-lesional skin and control group (P≤0.001). In addition, there was a significant difference in the expression of OPN, Ki-67, and CD34 between control and lesional group (P=0.02, P=0.02, and P=0.04, respectively). Conclusions: OPN expression seems to be related to Ki-67 (proliferation index) and CD34 expression (angiogenesis marker) confirming its role in the pathogenesis of psoriasis. Then "anti- OPN and anti-angiogenesis" may eventually become a useful therapeutic approach in psoriasis.en_US
dc.identifier.citationAmin Maha Mohamed, Azim Zeinab Abdel. Immunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt. Indian Journal of Pathology & Microbiology. 2012 Jan-Mar 55(1): 56-60.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142177
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=56;epage=60;aulast=Aminen_US
dc.subjectCD34en_US
dc.subjectKi-67en_US
dc.subjectosteopontinen_US
dc.subjectpsoriasisen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntigens, CD34 --analysis
dc.subject.meshChild
dc.subject.meshEgypt
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshKi-67 Antigen --analysis
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.subject.meshOsteopontin --analysis
dc.subject.meshPsoriasis --pathology
dc.subject.meshSkin --chemistry
dc.subject.meshSkin --pathology
dc.subject.meshYoung Adult
dc.titleImmunohistochemical study of osteopontin, Ki-67, and CD34 of psoriasis in Mansoura, Egypt.en_US
dc.typeArticleen_US
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