Microbial Profile of Neonatal Septicemia and its Antibiogram Prevalent in a Tertiary Care Hospital of Western Odisha

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dc.contributor.authorGhosh, Tanushreeen_US
dc.contributor.authorJena, Swetalinaen_US
dc.contributor.authorBehera, Aruna Ranien_US
dc.contributor.authorPanigrahy, Sangeetaen_US
dc.contributor.authorSethi, Rajesh Kumaren_US
dc.date.accessioned2023-06-17T08:34:51Z
dc.date.available2023-06-17T08:34:51Z
dc.date.issued2022-08
dc.description.abstractIntroduction : A disseminated disease with positive Blood Culture during the first month of life and encompasses various systemic infections of the newborn such as septicemia, meningitis, pneumonia, arthritis, osteomyelitis and Urinary Tract Infection is defined as Neonatal Sepsis. It is one of the leading causes of morbidity and mortality amongst neonates of developing countries. Aim : To determine the microbial profile of Blood Culture-positive Septicemia cases and study their antimicrobial susceptibility pattern. Materials and Methods : Blood Culture and C-reactive Protein (CRP) estimation were done for all 220 clinically suspected neonates. All the pure Bacterial and Candida isolates were identified using standard biochemical tests. Antimicrobial susceptibility testing was done for all bacterial isolates using the Kirby-Bauer disk diffusion method as per Clinical and Laboratory Standards Institute (CLSI) guidelines. Results : Out of 220 cases, 68.2% were culture positive. Early-onset Neonatal Septicemia (EONS) cases were 74% and Late-onset Neonatal Septicemia (LONS) 26%. The male to female ratio was 1.9:1. Bacterial cases were 66% and 34% were due to Candida. Gram-negative isolates predominated, with Klebsiella pneumonia being the most common one. In the case of Gram-positive isolates, Staphylococcus aureus was most common. The best overall sensitivity of Gram-negative isolates was to Amikacin (100%), Colistin (100%), and Imipenem (96%). Grampositive isolates reported 100% sensitivity to Vancomycin, Teicoplanin and 97.4% to Linezolid. Conclusion : Gram-negative isolates were the leading cause of Sepsis in our study. Strict antimicrobial stewardship should be implemented to prevent the emergence of multi-drug resistant strains.en_US
dc.identifier.affiliationsMD (Microbiology), Demonostrator, Department of Microbiology, Murshidabad Medical College and Hospital, Berhampore 742101 Corresponding Authoren_US
dc.identifier.affiliationsMD (Microbiology), Assistant Professor, Department of Microbiology, VSS Institute of Medical Science and Research, Burla, Odisha 768017en_US
dc.identifier.affiliationsMD (Microbiology), Assistant Professor, Department of Microbiology, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh 532484en_US
dc.identifier.affiliationsMD (Microbiology), Assistant Professor, Department of Microbiology, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh 532484en_US
dc.identifier.affiliationsMD (Paediatrics), Professor, Department of Paediatrics, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh 532484en_US
dc.identifier.citationGhosh Tanushree, Jena Swetalina, Behera Aruna Rani, Panigrahy Sangeeta, Sethi Rajesh Kumar. Microbial Profile of Neonatal Septicemia and its Antibiogram Prevalent in a Tertiary Care Hospital of Western Odisha. Journal of The Indian Medical Association. 2022 Aug; 120(8): 17-22en_US
dc.identifier.issn0019-5847
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216592
dc.languageenen_US
dc.publisherIndian Medical Associationen_US
dc.relation.issuenumber8en_US
dc.relation.volume120en_US
dc.source.urihttps://www.onlinejima.com/read_journals.php?article=994en_US
dc.subjectNeonatal septicemiaen_US
dc.subjectBlood cultureen_US
dc.subjectCRPen_US
dc.subjectAntimicrobial susceptibilityen_US
dc.titleMicrobial Profile of Neonatal Septicemia and its Antibiogram Prevalent in a Tertiary Care Hospital of Western Odishaen_US
dc.typeJournal Articleen_US
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