Clostridium Difficile is associated with High Mortality among Cirrhotics in India

Jayalakshmi, Vadivukkarasi Thangaraju; Anandan, Shalini; Zachariah, Uday George; Goel, Ashish; Veeraraghavan, Balaji; Kattiparambil, Sajith; Eapen, CE

Clostridium Difficile is associated with High Mortality among Cirrhotics in India

Date

2022-03

Authors

Jayalakshmi, Vadivukkarasi Thangaraju

Anandan, Shalini

Zachariah, Uday George

Goel, Ashish

Veeraraghavan, Balaji

Kattiparambil, Sajith

Eapen, CE

Publisher

All India Institute of Medical Sciences

Abstract

Background: To assess the prevalence and impact of Clostridium difficile infection (CDI) in hospitalized patients with cirrhosis in India. Methods: In this prospective observational study from June 2015 to March 2016, all hospitalized patients with cirrhosis and acute diarrhea at the time of admission or during hospitalization were included. We studied hospitalized patients with cirrhosis without diarrhea during the same period to detect asymptomatic colonizers.Stool samples were tested for CDI, bacterial cultures, and parasite microscopy in patients with diarrhea.CDI was detected using a stool PCR test that detects the pathogenicity locus of toxigenic Clostridium difficile gene. We analysed the impact of CDI on hospital outcomes and also assessed the risk factors for acquiring CDI. Result: Among 92 hospitalized cirrhotic patients with acute diarrhea [male: 74; median age: 50 (range 19 to 80) years; Child’s class A: B: C: 8:41:43; median MELD score: 18 (range 6 to 44)], 6 (6.5%) had CDI by positive stool PCR. Use of antibiotics (100% CDI Vs 55.8% non-CDI, p= 0.04) and steroids (50% CDI vs 10.5% non-CDI, p =0.028) emerged as risk factors for CDI among cirrhosis patients. Two of the 6 patients (33.3%) with CDI as compared to 6/86 patients (7%) with no CDI died (p-value: 0.08).There were no asymptomatic colonizers amongst 35 hospitalized cirrhosis patients without diarrhea.Conclusions: C. difficile, although uncommon, was an important cause of mortality in cirrhosis patients hospitalized with diarrhea in India.Prior use of antibiotics or steroids were identified as risk factors for CDI.

Keywords

Antibiotic-associateddiarrhea, Cirrhosis, Clostridium difficile

Citation

Jayalakshmi Vadivukkarasi Thangaraju, Anandan Shalini, Zachariah Uday George, Goel Ashish, Veeraraghavan Balaji, Kattiparambil Sajith, Eapen CE . Clostridium Difficile is associated with High Mortality among Cirrhotics in India. Tropical Gastroenterology. 2022 Mar; 43(1): 34-40