Efficacy of Fecal Microbiota Transplant in Patients with Moderate or Severe Irritable Bowel Syndrome in India

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dc.contributor.authorSeth, Avnish Kumaren_US
dc.contributor.authorSaxena, Kritikaen_US
dc.contributor.authorParikh, Samiren_US
dc.date.accessioned2023-07-21T11:38:53Z
dc.date.available2023-07-21T11:38:53Z
dc.date.issued2021-12
dc.description.abstractBackground and Aim: To study effect of FMT in patients with moderate or severe IBS. Methods: Patients with IBS for more than one year were offered three sessions of colonoscopicFMT in addition to standard of care. Severity of disease, psychological distress and QOL were assessed by IBS-SSS, HAM-D, HAM-A and WHO-QOL scores. Results: Ten patients with IBS (IBS-D 5, IBS-C 4 and IBS-M 1) were studied. Median IBS-SSS reduced from 313.5 (SD ± 66.8) at baseline to 163 (SD ± 84.5) at 1 week (p = 0.0005), 216 (SD ± 79.3) at 2 weeks (p = 0.003), 201(SD ± 86.6) at 4 weeks (p = 0.005) and 262 (SD ± 69.4) at 8 weeks. Median IBS-SSS at 12 weeks and 24 weeks was not significantly different from baseline. Reduction of IBS-SSS severity was seen in 8 (80%) patients at one week, 6(60%) at 2 and 4 weeks, 3(30%) at 8 weeks and 1(10%) at 12 and 24 weeks. weeks. Of four patients with depression, there was improvement in two patients at 2 and 4 weeks and one at 8 weeks. Quality of life improved in four patients at 2, 4 and 8 weeks, two patients at 12 weeks and one at 24 weeks. Three patients reported marked improvement of symptoms at 12 months along with change in stool odor to donor type. Conclusion: FMT results in short-term improvement in global symptoms of IBS, psychological distress and QOL. Repeat sessions of FMT did not accrue additional benefit.en_US
dc.identifier.affiliationsDepartment of Gastroenterology & Hepatobiliary Sciencesen_US
dc.identifier.affiliationsDepartment Mental Health & Behavioural Sciences, Fortis Memorial Research Institute, Sector 44, Gurugram, Haryana, India.en_US
dc.identifier.citationSeth Avnish Kumar, Saxena Kritika, Parikh Samir. Efficacy of Fecal Microbiota Transplant in Patients with Moderate or Severe Irritable Bowel Syndrome in India. Tropical Gastroenterology. 2021 Dec; 42(4): 189-197en_US
dc.identifier.issn0250-636X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221068
dc.languageenen_US
dc.publisherAll India Institute of Medical Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume42en_US
dc.source.urihttps://dx.doi.org/10.7869/tg.651en_US
dc.subjectIrritable Bowel Syndromeen_US
dc.subjectFecal Microbiota Transplanten_US
dc.subjectColonoscopic FMT.en_US
dc.titleEfficacy of Fecal Microbiota Transplant in Patients with Moderate or Severe Irritable Bowel Syndrome in Indiaen_US
dc.typeJournal Articleen_US
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