The pathogenesis of raised serum alpha-fetoprotein levels in amoebic and pyogenic hepatic abscesses.

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dc.contributor.authorAmanjee, Sen_US
dc.contributor.authorKew, M Cen_US
dc.contributor.authorVan Staden, Len_US
dc.date.accessioned1990-04-01en_US
dc.date.accessioned2009-06-04T04:11:45Z
dc.date.available1990-04-01en_US
dc.date.available2009-06-04T04:11:45Z
dc.date.issued1990-04-01en_US
dc.description.abstractSerum alpha-fetoprotein (AFP) concentrations may be slightly raised in patients with amoebic hepatic abscesses. In an attempt to learn more about the pathogenesis of the raised levels, we studied 74 patients with amoebic and six with pyogenic hepatic abscesses. Serum (AFP) levels were slightly elevated (24-72 ng/ml) on admission in four patients and markedly raised (2000 ng/ml) in one, who had hepatocellular carcinoma in addition to a pyogenic hepatic abscess. The pattern of the early rise in AFP levels could not be determined because these four patients were lost to follow-up. However, serial serum AFP estimations were obtained in 29 patients with a normal value on admission and in none of these did the concentration rise during recovery. Our findings do not support the prevailing hypothesis that regenerating hepatocytes are responsible for the raised serum AFP levels in non-neoplastic hepatic disorders, including hepatic abscesses.en_US
dc.description.affiliationDepartment of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.en_US
dc.identifier.citationAmanjee S, Kew MC, Van Staden L. The pathogenesis of raised serum alpha-fetoprotein levels in amoebic and pyogenic hepatic abscesses. Tropical Gastroenterology. 1990 Apr-Jun; 11(2): 99-102en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124766
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshAspartate Aminotransferases --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Abscess --blooden_US
dc.subject.meshLiver Abscess, Amebic --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTime Factorsen_US
dc.subject.meshalpha-Fetoproteins --analysisen_US
dc.titleThe pathogenesis of raised serum alpha-fetoprotein levels in amoebic and pyogenic hepatic abscesses.en_US
dc.typeJournal Articleen_US
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