Enhancement of insulin hypoglycaemia by beta adrenoceptor antagonists.

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dc.contributor.authorSingh, R Cen_US
dc.contributor.authorSrivastava, V Ken_US
dc.contributor.authorTayal, Gen_US
dc.contributor.authorSrivastava, R Ken_US
dc.contributor.authorPrasad, D Nen_US
dc.date.accessioned1978-01-01en_US
dc.date.accessioned2009-06-01T07:10:58Z
dc.date.available1978-01-01en_US
dc.date.available2009-06-01T07:10:58Z
dc.date.issued1978-01-01en_US
dc.description.abstractInteraction of insulin with beta-adrenoceptor antagonists was studied in conscious rabbits. Propranolol and metoprolol did not modify the peak of insulin hypoglycaemia but delayed its recovery. Practolol, sotalol and 1-INPEA enhanced the peak effect and delayed the recovery of insulin-induced hypoglycaemia. H 35/25 and d-INPEA did not modify insulin hypoglycaemia. The beta-blockers did not produce significant hypoglycaemia per se. Since sotalol, 1-INPEA (specific beta-adrenoceptor antagonists devoid of local anaesthetic activity); practolol and metoprolol (selective cardiac beta-1 adrenoceptor antagonists) enhanced hypoglycaemic action of insulin and H 35/25 (a selective beta-2 adrenoceptor antagonist) failed to affect it, it seems that selective beta-adrenoceptor blockade (similar to cardiac beta-1 adrenoceptors) mediates enhancement of insulin hypoglycaemia. Caution should, therefore, be exercised in administering beta-adrenoceptor antagonists and insulin together. A reduction in the dose of insulin may be necessary.en_US
dc.identifier.citationSingh RC, Srivastava VK, Tayal G, Srivastava RK, Prasad DN. Enhancement of insulin hypoglycaemia by beta adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1978 Jan-Mar; 22(1): 61-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107959
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdrenergic beta-Antagonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshDepression, Chemicalen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshEpinephrine --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshInsulin --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRabbitsen_US
dc.titleEnhancement of insulin hypoglycaemia by beta adrenoceptor antagonists.en_US
dc.typeJournal Articleen_US
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