Clinical Profile of Interstitial Lung Disease in Indian Children.
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Date
2013-01
Journal Title
Journal ISSN
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Abstract
Objective: To describe the clinical spectrum and factors
associated with poor short-term outcomes in children with
interstitial lung disease (ILD).
Design: Retrospective chart review
Setting: Pediatric Chest Clinic of a tertiary care hospital
Methodology: We retrieved information regarding clinical course
and laboratory features of all children diagnosed as ILD between
January 1999 and February 2010. Disease severity was
assessed using ILD score based on clinical features and SpO2 at
the time of initial evaluation. Outcome was assessed after 3
months of initial diagnosis as improved or death/no improvement
in symptoms.
Results: 90 children (median age, 6.8 years; 62% boys) were
diagnosed to have ILD during this period. 46 children were
R E S E A R C H P A P E R
classified as having ‘definite ILD’ while 44 had ‘possible ILD’. The
commonest clinical features at presentation were cough (82.2%),
dyspnea (80%), pallor (50%), and crackles (45.6%). 3 children
(3.3%) died while 21 (23%) showed no improvement in clinical
status on follow-up at 3 months. A higher ILD score (RR 3.72, 95%
CI 1.4, 9.9) and lower alkaline phosphatase levels (median [IQR]:
205 [175.2] vs. 360 [245.7]; P=0.006) were found to be
significantly associated with worse outcomes.
Conclusion: The common clinical features of ILD in our study
included breathlessness, cough and hypoxemia. A working
diagnosis of ILD can be made with the help of imaging,
bronchoscopy, or lung biopsy. A simple score based on clinical
findings and pulse-oximetry might predict those children with poor
short-term outcome.
Description
Keywords
ILD, ILD score, Interstitial lung disease
Citation
Sankar Jhuma, Pillai Mrinal S, Sankar M Jeeva, Lodha Rakesh, Kabra Sushil K. Clinical Profile of Interstitial Lung Disease in Indian Children. Indian Pediatrics. 2013 January; 50(1): 127-133.