Gender differences in genotypic distribution of endothelin-1 gene and endothelin receptor A gene in pulmonary hypertension associated with rheumatic mitral valve disease

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dc.contributor.authorMehra, Pratishthaen_US
dc.contributor.authorMehta, Vimalen_US
dc.contributor.authorYusuf, Jamalen_US
dc.contributor.authorMukhopadhyay, Saibalen_US
dc.contributor.authorDabla, Pradeep Kumaren_US
dc.contributor.authorParashar, Lokeshen_US
dc.contributor.authorSukhija, Rishien_US
dc.contributor.authorAronow, Wilbert S.en_US
dc.date.accessioned2023-07-21T11:36:55Z
dc.date.available2023-07-21T11:36:55Z
dc.date.issued2022-10
dc.description.abstractIntroduction: The female gender is a risk factor for idiopathic pulmonary arterial hypertension. However, it is unknown whether females with rheumatic mitral valve disease are more predisposed to develop pulmonary hypertension compared to males. Aim: We aimed to investigate whether there was a difference in genotypic distribution of endothelin-1 (ET-1) and endothelin receptor A (ETA) genes between female and male patients of pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD). Methods: We compared prevalence of ET-1 gene (Lys198Asn) and ETA gene (His323His) polymorphisms according to gender in 123 PH-MVD subjects and 123 healthy controls. Results: The presence of mutant Asn/Asn and either mutant Asn/Asn or heterozygous Lys/Asn genotypes of Lys198Asn polymorphism when compared to Lys/Lys in females showed significant association with higher risk (odds ratio [OR] 4.5; p ¼0.007 and OR 2.39; p ¼0.02, respectively). The presence of heterozygous C/T and either mutant T/T or heterozygous C/T genotypes of His323His polymorphism when compared to wild C/C genotype in females showed a significant association with higher risk (OR 1.96; p ¼0.047 and OR 2.26; p ¼0.01, respectively). No significant difference was seen in genotypic frequencies in males between PH-MVD subjects and controls. Logistic regression analysis showed that mutant genotype Asn/Asn (p ¼0.007) and heterozygous genotype Lys/Asn of Lys198Asn polymorphism (p ¼0.018) were independent predictors of development of PH in females.en_US
dc.identifier.affiliationsDepartment of Cardiology, G. B. Pant Institute of Postgraduate Medical Education and Research, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, G. B. Pant Institute of Postgraduate Medical Education and Research, New Delhi, Indiaen_US
dc.identifier.affiliationsStatistician, ESIC Medical College and Hospital, Faridabad, Indiaen_US
dc.identifier.affiliationsDivision of Cardiology, University of Cincinnati College of Medicine, Cincinnati, OH, USAen_US
dc.identifier.affiliationsDepartment of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USAen_US
dc.identifier.citationMehra Pratishtha, Mehta Vimal, Yusuf Jamal, Mukhopadhyay Saibal, Dabla Pradeep Kumar, Parashar Lokesh, Sukhija Rishi, Aronow Wilbert S.. Gender differences in genotypic distribution of endothelin-1 gene and endothelin receptor A gene in pulmonary hypertension associated with rheumatic mitral valve disease. Indian Heart Journal. 2022 Oct; 74(5): 375-381en_US
dc.identifier.issn0019-4832
dc.identifier.issn2213-3763
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220928
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber5en_US
dc.relation.volume74en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2022.09.005en_US
dc.subjectPulmonary hypertensionen_US
dc.subjectRheumatic heart diseaseen_US
dc.subjectMitral stenosisen_US
dc.subjectEndothelin-1 gene polymorphismen_US
dc.subjectEndothelin receptor A gene polymorphismen_US
dc.subjectGenderen_US
dc.titleGender differences in genotypic distribution of endothelin-1 gene and endothelin receptor A gene in pulmonary hypertension associated with rheumatic mitral valve diseaseen_US
dc.typeJournal Articleen_US
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