Dyspnea, Obstruction, Smoking, Exacerbation Index, and Chronic Obstructive Pulmonary Disease Test Score: Correlation in Predicting Outcomes in Patients with Chronic Obstructive Pulmonary Disease Exacerbations
dc.contributor.author | Mishra, R | en_US |
dc.contributor.author | Daga, M K | en_US |
dc.contributor.author | Rohatgi, I | en_US |
dc.contributor.author | Mawari, G | en_US |
dc.contributor.author | Kumar, N | en_US |
dc.contributor.author | Hira, H | en_US |
dc.date.accessioned | 2023-08-09T06:06:27Z | |
dc.date.available | 2023-08-09T06:06:27Z | |
dc.date.issued | 2022-09 | |
dc.description.abstract | Objectives: Chronic obstructive pulmonary disease (COPD) being a disease with systemic consequences necessitate the use of multidimensional indices for a comprehensive assessment of the disease's impact including the future risk of exacerbations and mortality. To study the role of dyspnea, obstruction, smoking, and exacerbation (DOSE) index as a predictor of future disease severity and its correlation with chronic obstructive pulmonary disease test (CAT) score. Measurements and results: A total of 60 inpatients with COPD exacerbations were followed up for 6 months to record the number of exacerbations of COPD. The DOSE index and CAT score were calculated after stabilization within 48 hours of admission, at 1 week, and again at 6 months. The mean difference between DOSE index score at admission and at 1 week was 1.382 � 0.561 and at admission and at 6 months was 2.15 � 0.988, both being statistically significant (p < 0.001). A high DOSE index score (?4) was associated with a greater risk of 2 or more exacerbations [odds ratio (OR), 12 (3.09�.60) and risk estimate, 3.75 (1.53�17)]. For the prediction of exacerbations, the area under the curve (AUC) was larger for the DOSE index (0.854) than the global initiative for chronic obstructive lung disease (GOLD) stage (0.789), p < 0.001 for both. Furthermore, DOSE index correlated significantly with the CAT score, an established health status measure, at all stages of disease severity; at the onset of exacerbation (r = 0.719, p < 0.001), after stabilization at 1 week (r = 0.736, p < 0.001) and at 6 months (r = 0.884, p < 0.001). Conclusion: The DOSE index is a simple, practical multidimensional grading tool for assessing current symptoms, health status, and future risk in COPD and acts as a guide to disease management as its component items can be modified by interventions. Its correlation with CAT, a well-known score is a novel observation, which further corroborates the validity of the DOSE index. | en_US |
dc.identifier.affiliations | Department of Medicine, Maulana Azad Medical College, New Delhi, India | en_US |
dc.identifier.affiliations | Department of Pulmonary Medicine, Maulana Azad Medical College, New Delhi, India | en_US |
dc.identifier.citation | Mishra R, Daga M K, Rohatgi I, Mawari G, Kumar N, Hira H.. Dyspnea, Obstruction, Smoking, Exacerbation Index, and Chronic Obstructive Pulmonary Disease Test Score: Correlation in Predicting Outcomes in Patients with Chronic Obstructive Pulmonary Disease Exacerbations . Indian Journal of Chest Diseases & Allied Sciences. 2022 Sep; 64(3): 153-159 | en_US |
dc.identifier.issn | 0377-9343 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/221814 | |
dc.language | en | en_US |
dc.publisher | Jaypee Brothers Medical Publishers Pvt. Ltd | en_US |
dc.relation.issuenumber | 3 | en_US |
dc.relation.volume | 64 | en_US |
dc.source.uri | https://doi.org/10.5005/jp-journals-11007-0049 | en_US |
dc.subject | Chronic obstructive pulmonary disease | en_US |
dc.subject | Chronic obstructive pulmonary disease test | en_US |
dc.subject | Dyspnea | en_US |
dc.subject | Obstruction | en_US |
dc.subject | smoking | en_US |
dc.subject | and exacerbation index | en_US |
dc.subject | Global initiative for chronic obstructive lung disease | en_US |
dc.title | Dyspnea, Obstruction, Smoking, Exacerbation Index, and Chronic Obstructive Pulmonary Disease Test Score: Correlation in Predicting Outcomes in Patients with Chronic Obstructive Pulmonary Disease Exacerbations | en_US |
dc.type | Journal Article | en_US |
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