Large cryptic internal sequence repeats in protein structures from Homo sapiens.
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Date
2009-03
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Abstract
Amino acid sequences are known to constantly mutate and diverge unless there is a limiting condition that makes
such a change deleterious. However, closer examination of the sequence and structure reveals that a few large,
cryptic repeats are nevertheless sequentially conserved. This leads to the question of why only certain repeats are
conserved at the sequence level. It would be interesting to fi nd out if these sequences maintain their conservation at
the three-dimensional structure level. They can play an active role in protein and nucleotide stability, thus not only
ensuring proper functioning but also potentiating malfunction and disease. Therefore, insights into any aspect of the
repeats – be it structure, function or evolution – would prove to be of some importance. This study aims to address
the relationship between protein sequence and its three-dimensional structure, by examining if large cryptic sequence
repeats have the same structure.
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Sarani R, Udayaprakash N A, Subashini R, Mridula P, Yamane T, Sekar K. Large cryptic internal sequence repeats in protein structures from Homo sapiens. Journal of Biosciences. 2009 Mar; 34(1): 103-112.