Comparative Analysis of Sensitivity and Specificity of Creatinine Kinase MB and Cardiac Troponin I for the Diagnosis of Acute Myocardial Infarction
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Date
2024-12
Journal Title
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Publisher
THE INDIAN MEDICAL ASSOCIATION
Abstract
Background : Early diagnosis is of crucial importance for the successful management of individuals with Acute Myocardial Infarction and is one of the leading causes of mortality and morbidity. We aimed to determine the sensitivity and specificity of two markers commonly used in our institution to diagnose patients with complaints indicative of Acute Myocardial Infarction. Material and Methods : Patients admitted to the tertiary care center with complaints of chest pain were screened. Creatine Kinase Myoglobin Binding (CKMB) and Cardiac Troponin I (cTnI) were performed by following standard protocols. Depending upon the onset of chest pain subjects were divided into two groups, Group 1 : Within 24 hours of chest pain, Group 2 : Within 24-72 hours of chest pain. They were subdivided based on a diagnosis of MI. Results were used to calculate the specificity and sensitivity of CKMB, cTnI, and CKMB and cTnI together. Results : Total of 368 patients were studied. Majority of them were >60 years of age. Of these, 133(36%) had confirmed diagnosis of MI. CKMB is more sensitive (82.19%) within 24 hours of MI but after 24 hours sensitivity decreases to (57.53%). CKMB is specific after 24 hours of MI (92.26%) compared to within 24 hours of MI (65.81%) whereas, cTnI is more specific (95.00%) after 24 hours. Conclusion : For the diagnosis of Acute Myocardial Infarction (AMI), CKMB is more sensitive and cTnI is more specific, therefore it will be better if we perform cTnI rapid card test in combination with CKMB.
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Keywords
CKMB, cTnI, Acute Myocardial Infarction, Sensitivity, Specificity
Citation
Purandare Nidhi Rohan, Goyal Astha, Shinde Sarita, Jain Shilpa . Comparative Analysis of Sensitivity and Specificity of Creatinine Kinase MB and Cardiac Troponin I for the Diagnosis of Acute Myocardial Infarction. Journal of the Indian Medical Association. 2024 Dec; 122(12): 47-51