Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of six cases.

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dc.contributor.authorRumana, Men_US
dc.contributor.authorSantosh, Vanien_US
dc.contributor.authorKhursheed, Nen_US
dc.contributor.authorYasha, T Cen_US
dc.contributor.authorKolluri, V R Sen_US
dc.contributor.authorShetty, Sen_US
dc.contributor.authorRavi, Kumar C Ven_US
dc.date.accessioned2007-07-22en_US
dc.date.accessioned2009-05-29T11:31:46Z
dc.date.available2007-07-22en_US
dc.date.available2009-05-29T11:31:46Z
dc.date.issued2007-07-22en_US
dc.description.abstractSpinal paragangliomas are uncommon neoplasms and subject of much debate regarding the factors governing their biological behaviour. We describe the clinicopathological and immunohistochemical (IHC) features of six cases of spinal paraganglioma. The mean age of patients was 40 years (range 20-60 years) with a male to female ratio of (2:1). Majority presented with low backache, sphincter disturbances and sensory symptoms. All tumors were intradural in the cauda region one of them extending to the filum. Only one showed focal extradural extension on microscopy. Gross total resection of tumors was possible in all cases. Histologically four showed classical 'zell-ballen' pattern and two revealed an ependymal morphology. On immunohistochemistry, in all the six cases the chief cells were intensely labeled by antibody to chromogranin but not for GFAP while staining for synaptophysin was less intense and variable in five. Sustentacular cells in all cases showed strong expression for S-100 protein and chief cells were stained light in three cases. Low MIB-1 labeling index of 0.01-2% was noted in five cases and in the sixth it was 5%. None of the tumours recurred. Immunohistochemistry assisted in differentiating these relatively benign neural crest tumours from the more aggressive spinal ependymomas.en_US
dc.description.affiliationDepartment of Neuropathology, NIMHANS, Bangalore.en_US
dc.identifier.citationRumana M, Santosh V, Khursheed N, Yasha TC, Kolluri VR, Shetty S, Ravi KC. Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of six cases. Indian Journal of Pathology & Microbiology. 2007 Jul; 50(3): 528-32en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73613
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParaganglioma --pathologyen_US
dc.subject.meshSpinal Neoplasms --pathologyen_US
dc.titlePrimary spinal paragangliomas: a clinicopathological and immunohistochemical study of six cases.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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