Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other.

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dc.contributor.authorSachdev, Ritesh
dc.contributor.authorTiwari, Aseem K
dc.contributor.authorGoel, Shalini
dc.contributor.authorRaina, Vimarsh
dc.contributor.authorSethi, Monisha
dc.date.accessioned2015-02-13T06:35:14Z
dc.date.available2015-02-13T06:35:14Z
dc.date.issued2014-04
dc.description.abstractAims: This study aims to establish biological reference interval for novel platelet parameters. Settings and Design: A total of 945 healthy individuals, age ranges from 18 to 64 years (881 males and 64 females) coming for voluntary blood donation from June to August 2012 (3 months) were enrolled after exclusion of rejection criteria. Materials and Methods: The samples were assayed by running in complete blood count + reticulocyte mode on the Sysmex XE-2100 hematology analyzer and the reference interval for the population was calculated using Clinical and Laboratory Standards Institute guidelines. Statistical analysis used: Tests were performed using SPSS (Statistical Product and Service Solutions , developed by IBM corporation), version 13. Student t test and pearsons correlation analysis were also used. Results: The normal range for various parameters was platelet count: 150-520 × 103/cu mm, immature platelet fraction (IPF): 0.3-8.7%, platelet distribution width (PDW): 8.3-25.0 fL, mean platelet volume (MPV): 8.6-15.5 fL, plateletcrit (PCT): 0.15-0.62%, high immature platelet fraction (H-IPF): 0.1-2.7%, platelet large cell ratio (P-LCR): 11.9-66.9% and platelet-X (PLT-X) (ch): 11.0-22.0. Negative correlation was observed between platelet count (r = −0.468 to r = −0.531; P < 0.001) and PCT (r = −0.080 to r = −0.235; P < 0.05 to P < 0.001) with IPF, PDW, MPV, H-IPF, P-LCR, and platelet-X. IPF/H-IPF showed a positive correlation among them and also with PDW, MPV, P-LCR, platelet-X (r = +0.662 to r = +0.925; P < 0.001). Conclusions: These novel platelet parameters offer newer avenues in research and clinical use. Establishing biological reference interval for different platelet parameters would help determine true high and low values and help guide treatment decisions.en_US
dc.identifier.citationSachdev Ritesh, Tiwari Aseem K, Goel Shalini, Raina Vimarsh, Sethi Monisha. Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other. Indian Journal of Pathology & Microbiology. 2014 Apr-Jun 57 (2): 231-235.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156020
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=2;spage=231;epage=235;aulast=Sachdeven_US
dc.subjectHigh immature platelet fractionen_US
dc.subjectimmature platelet fractionen_US
dc.subjectplatelet distribution widthen_US
dc.subjectplatelet large cell ratioen_US
dc.subjectreference intervalen_US
dc.titleEstablishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other.en_US
dc.typeArticleen_US
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