End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients
| dc.contributor.author | Singh, Sanjay | en_US |
| dc.contributor.author | Shukla, Prakriti | en_US |
| dc.date.accessioned | 2020-01-02T06:51:21Z | |
| dc.date.available | 2020-01-02T06:51:21Z | |
| dc.date.issued | 2018-09 | |
| dc.description.abstract | Background: There is a general impression among dermatologists in India that terbinafine has been losing its effectiveness in dermatophytoses over the past few years, but there are no recent data to support this. Aims: To determine the effectiveness of terbinafine in tinea corporis, tinea cruris and tinea faciei with a pragmatic prospective cohort study. Methods: A sample size of 361 patients was calculated taking a 5% margin of error and a 95% confidence level. Five hundred patients with tinea corporis, tinea cruris and tinea faciei confirmed by potassium hydroxide microscopy received oral terbinafine (5mg/kg/day) and topical terbinafine 1% applied twice daily for 4 weeks. Patients were evaluated at 2 and 4 weeks. Cure was defined as total clearance of lesions and negative microscopy. Results: Patients who came for follow-up at 2 and 4 weeks numbered 357 and 362 respectively. Ten patients were cured at 2 weeks (cure rate 2%, 95% confidence interval 1.0–3.7%, intention-to-treat analysis) and 153 patients were cured at 4 weeks (cure rate 30.6%, 95% confidence interval 26.7–34.8%). Limitations: Culture and antifungal susceptibility testing were not performed since this was a pragmatic study. There was also no follow up after completion of treatment to check for relapses, but the poor response makes this less relevant. Conclusion: The effectiveness of terbinafine in dermatophytosis was abysmal in this study. | en_US |
| dc.identifier.affiliations | Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India | en_US |
| dc.identifier.citation | Singh Sanjay, Shukla Prakriti. End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients. Indian Journal of Dermatology, Venereology and Leprology. 2018 Sep; 84(5): 554-557 | en_US |
| dc.identifier.issn | 0378-6323 | |
| dc.identifier.issn | 0973-3922 | |
| dc.identifier.place | India | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/192415 | |
| dc.language | en | en_US |
| dc.publisher | Indian Association of Dermatologists, Venereologists & Leprologists | en_US |
| dc.relation.issuenumber | 5 | en_US |
| dc.relation.volume | 84 | en_US |
| dc.source.uri | https://dx.doi.org/10.4103/ijdvl.IJDVL_526_17 | en_US |
| dc.subject | Dermatophytes | en_US |
| dc.subject | dermatophytosis | en_US |
| dc.subject | terbinafine | en_US |
| dc.subject | tinea | en_US |
| dc.title | End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients | en_US |
| dc.type | Journal Article | en_US |
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