Epidermal growth factor receptor mutation subtypes and geographical distribution among Indian non-small cell lung cancer patients.
Loading...
Date
2013-04
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center
in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish
23% EGFR mutation frequency among Indian population. Here, we extend our study and report further analysis of distribution
of different types of EGFR mutations in 1018 non small cell lung cancer patient, and its co-relation with clinical parameters
and geographical variations across the country. Material and Methods: This study is a retrospective analysis on all the
patients who were referred for EFGR testing as a routine service over a 1.5 year period. This was part of standard care.
EGFR kinase domain mutations in exon 18-21 were probed by TaqMan probe-based assays in 1018 NSCLC patients.
Results and Discussion: While EGFR exon 19 mutations, the most frequent EGFR mutation, were found be higher
among non smokers females, we find surprisingly higher incidence of exon 21 mutations among EGFR mutation positive
male smokers of Indian ethnicity. Furthermore, as Indian population is known to be composed of a gradient admixture of
Ancestral North Indian (with genetic influence from Middle Easterners, Central Asians, and Europeans harboring variant
EGFR mutation frequency) and Ancestral South Indians, as a paradox our study indicates comparable EGFR mutation
frequency across different geographical locations within India Conclusion: Geographically there is uniform distribution in
the EGFR mutation frequency within India. Further more, while exon 19 mutations are predominant among non smokers,
higher incidence of exon 21 mutations exists among EGFR mutation positive male smokers of Indian ethnicity.
Description
Keywords
Non–small cell lung cancer, epidermal growth factor receptor, adenocarcinoma, real‑time PCR
Citation
Choughule A, Noronha V, Joshi A, Desai S, Jambhekar N, Utture S, Thavamanni A, Prabhash K, Dutt A. Epidermal growth factor receptor mutation subtypes and geographical distribution among Indian non-small cell lung cancer patients. Indian Journal of Cancer. 2013 Apr-June; 50(2): 107-111.