Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib.

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dc.contributor.authorKesharwani, Roohi
dc.contributor.authorSachan, Anupam
dc.contributor.authorSingh, Swati
dc.contributor.authorPatel, Dilip
dc.date.accessioned2016-12-26T10:22:43Z
dc.date.available2016-12-26T10:22:43Z
dc.date.issued2016-10
dc.description.abstractThe objective of present investigation was to prepare & evaluate solid lipid nanoparticle (SLN) based topical gel of non- steroidal anti-inflammatory drug (NSAID) etoricoxib for the treatment of arthritis which would attenuate the gastrointestinal related toxicities associated with oral administration. SLN were formulated by melt emulsification and solidification at low temperature method using stearic acid & tween 80. All the formulation were subjected to particle size, particle size distribution, zeta potential, scanning electron microscopy, crystallinity study by DSC and in-vitro release studies. It has been observed that, the high lipid concentration containing formulation have higher entrapment as compare to other two formulation. The SLN- dispersion shows 70.766% entrapment & zeta potential of the formulation were -25.6 which indicates the stability of formulation. The In Vitro drug release rate of gel was evaluated using Modified franz diffusion cell containing dialysis membrane with phosphate buffer pH 7.4 as the receptor medium. The in-vitro release was carried out in comparison with a carbopol gel & hydroxypropylmethylcellulose (HPMC) gel. The permeability parameters steady-state flux (Jss) was significantly increased in SLN-F3C (carbopol) formulation as compared with SLN-F3HPMC (hydroxypropyl methylcellulose) formulation. It was concluded that the Etoricoxib loaded SLN based gel formulation containing carbopol was suitable for topical application and shows much better result of anti-inflammatory activity.en_US
dc.identifier.citationKesharwani Roohi , Sachan Anupam, Singh Swati , Patel Dilip. Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib. Journal of Applied Pharmaceutical Science. 2016 Oct; 6(10): 124-131.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/180469
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=2023en_US
dc.subjectEtoricoxiben_US
dc.subjectsolid lipid nanoparticle (SLN)en_US
dc.subjecttopical gelen_US
dc.subjectdiffusion cell.en_US
dc.titleFormulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib.en_US
dc.typeArticleen_US
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