Interactions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease.

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dc.contributor.authorSingh, B Ken_US
dc.contributor.authorMehta, J Len_US
dc.date.accessioned2001-07-05en_US
dc.date.accessioned2009-05-27T04:22:20Z
dc.date.available2001-07-05en_US
dc.date.available2009-05-27T04:22:20Z
dc.date.issued2001-07-05en_US
dc.description64 references.en_US
dc.description.abstractHypertension and hypercholesterolemia, two major risk factors for atherosclerotic disease, frequently coexist in patients with hypertension and CAD. Data from clinical studies suggest the existence of lipoprotein-neurohormonal interactions that may adversely affect vascular structure and reactivity. Data from preclinical studies suggest that RAS may be upregulated by abnormal lipids, most likely via production of ox-LDL. On the other hand, activation of RAS leads to release of ROS and transcriptional upregulation of LDL and ox-LDL uptake in macrophages, smooth muscle cells and endothelial cells. These findings extend our understanding of the interplay among risk factors to synergistically increase cardiovascular risk, and of the anti-atherosclerotic effects of local ACE inhibition to reduce cardiovascular risk. Trials aimed at modifying RAS along with drugs lowering total- and LDL-cholesterol levels and inhibitors of oxidative modification of LDL-cholesterol will address the clinical relevance of this biological interaction.en_US
dc.description.affiliationDepartment of Internal Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock 72205, USA.en_US
dc.identifier.citationSingh BK, Mehta JL. Interactions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease. Indian Heart Journal. 2001 Jul-Aug; 53(4): 511-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4251
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteriosclerosis --physiopathologyen_US
dc.subject.meshCoronary Disease --physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperlipidemias --physiopathologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRenin-Angiotensin System --physiologyen_US
dc.titleInteractions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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