Interactions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease.
dc.contributor.author | Singh, B K | en_US |
dc.contributor.author | Mehta, J L | en_US |
dc.date.accessioned | 2001-07-05 | en_US |
dc.date.accessioned | 2009-05-27T04:22:20Z | |
dc.date.available | 2001-07-05 | en_US |
dc.date.available | 2009-05-27T04:22:20Z | |
dc.date.issued | 2001-07-05 | en_US |
dc.description | 64 references. | en_US |
dc.description.abstract | Hypertension and hypercholesterolemia, two major risk factors for atherosclerotic disease, frequently coexist in patients with hypertension and CAD. Data from clinical studies suggest the existence of lipoprotein-neurohormonal interactions that may adversely affect vascular structure and reactivity. Data from preclinical studies suggest that RAS may be upregulated by abnormal lipids, most likely via production of ox-LDL. On the other hand, activation of RAS leads to release of ROS and transcriptional upregulation of LDL and ox-LDL uptake in macrophages, smooth muscle cells and endothelial cells. These findings extend our understanding of the interplay among risk factors to synergistically increase cardiovascular risk, and of the anti-atherosclerotic effects of local ACE inhibition to reduce cardiovascular risk. Trials aimed at modifying RAS along with drugs lowering total- and LDL-cholesterol levels and inhibitors of oxidative modification of LDL-cholesterol will address the clinical relevance of this biological interaction. | en_US |
dc.description.affiliation | Department of Internal Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock 72205, USA. | en_US |
dc.identifier.citation | Singh BK, Mehta JL. Interactions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease. Indian Heart Journal. 2001 Jul-Aug; 53(4): 511-8 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/4251 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://indianheartjournal.com | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arteriosclerosis --physiopathology | en_US |
dc.subject.mesh | Coronary Disease --physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hyperlipidemias --physiopathology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Renin-Angiotensin System --physiology | en_US |
dc.title | Interactions between the renin-angiotensin system and dyslipidemia: relevance in atherogenesis and therapy of coronary heart disease. | en_US |
dc.type | In Vitro | en_US |
dc.type | Journal Article | en_US |
dc.type | Review | en_US |
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