Comparison of Urinary Protein Creatinine Index (uPCI) and Dipsticks for the Prediction of Renal Dysfunction in Chronic Cigarette Smokers.

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dc.contributor.authorKapoor, Sangeeta
dc.contributor.authorMehta, Debojit Kumar
dc.contributor.authorYadav, Sushil
dc.contributor.authorVerma, Anjali
dc.contributor.authorMathur, Shipra
dc.date.accessioned2015-08-19T09:02:31Z
dc.date.available2015-08-19T09:02:31Z
dc.date.issued2015-01
dc.description.abstractBackground: Proteinuria is recognized as one of the earliest sign of renal function deterioration in chronic smokers. Proteinuria occurs due to alteration in glomerular permeability and later due to failure of reabsorption of filtered protein by the tubular cells. Normally, most healthy adults excrete 20 – 150 mg of protein in urine over 24 hours. However, it is difficult to collect 24 hrs urine samples. Objectives: To advocate the use of PCI (protein creatinine index) in assessment of proteinuria and to compare dipstick result with PCI in the assessment of proteinuria in chronic cigarette smokers. Material & Methods: A total of 30 cigarette smokers and 40 age and sex matched controls were included for the study. A random specimen of urine collected from each cigarette smoker and non- smoker was tested quantitatively by manual sulfosalicylic acid colorimetric method for the estimation of protein concentration. Creatinine concentration in each specimen was measured by modified Jaffe’s method and the urinary PCI was calculated. Results: Normal range of PCI which has been established in this study is 50 to 259. Significantly higher amounts of protein were found to be excreted in urine in chronic smokers (9.313 ± 4.003 mg/dl) as compared to healthy non smokers (7.738 ± 2.05 mg/dl). On comparison of PCI between healthy non smoker and chronic smoker subjects, PCI has been found to be significantly elevated in chronic smokers (healthy non smoker- 118.32 ± 56.86, chronic smoker- 180.1 ± 88.23) (p=0.001). Conclusion: PCI of random urine sample can provide a very useful, simple and convenient method for the quantitative assessment of proteinuria to confirm the advent of kidney damage, avoiding the drawbacks of 24 hrs urine collection.en_US
dc.identifier.citationKapoor Sangeeta, Mehta Debojit Kumar, Yadav Sushil, Verma Anjali, Mathur Shipra. Comparison of Urinary Protein Creatinine Index (uPCI) and Dipsticks for the Prediction of Renal Dysfunction in Chronic Cigarette Smokers. Acta Medica International. 2015 Jan-Jun: 2(1): 96-99.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162089
dc.language.isoenen_US
dc.source.urihttps://www.actamedicainternational.com/Article.aspx?id=53&volume=2&issue=1&type=1en_US
dc.subjectProteinuriaen_US
dc.subjectPCI (Protein Creatinine Index) and dipsticken_US
dc.subject.meshAdult
dc.subject.meshHumans
dc.subject.meshCreatinine --analysis
dc.subject.meshCreatinine --urine
dc.subject.meshProteinuria --analysis
dc.subject.meshProteinuria --diagnosis
dc.subject.meshProteinuria --urine
dc.subject.meshReagent Strips --diagnostic use
dc.subject.meshRenal Insufficiency --diagnosis
dc.subject.meshRenal Insufficiency --urine
dc.subject.meshSmoking --adverse effects
dc.subject.meshSmoking --urine
dc.subject.meshYoung Adult
dc.titleComparison of Urinary Protein Creatinine Index (uPCI) and Dipsticks for the Prediction of Renal Dysfunction in Chronic Cigarette Smokers.en_US
dc.typeArticleen_US
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