Splenic Dysfunction in Children With Sickle Cell Disease: A Single Centre Experience From Central India

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dc.contributor.authorJohns, Julieten_US
dc.contributor.authorGoel, Anil Kumaren_US
dc.contributor.authorJondhale, Sunilen_US
dc.contributor.authorVenkatesan, Dilip Kumaren_US
dc.contributor.authorRavina, Mudalshaen_US
dc.contributor.authorShah, Seemaen_US
dc.contributor.authorSyal, Simranen_US
dc.date.accessioned2025-05-09T10:00:42Z
dc.date.available2025-05-09T10:00:42Z
dc.date.issued2024-09
dc.description.abstractObjective: To assess the prevalence and predictors of splenic dysfunction in children with sickle cell disease (SCD). Methods: A cross-sectional study was conducted between June 2019 and December 2020 where children aged 1 to 15 years of age with SCD were screened for splenic dysfunction. Children who were splenectomised, those with other diseases known to affect splenic function like congenital malformations, immunodeficiencies, and chronic diseases like tuberculosis, nephrotic syndrome, diabetes mellitus, chronic liver disease, celiac disease or malignancy were excluded. Splenic size was assessed by clinical examination and ultrasonography. Splenic dysfunction was assessed by Technetium-99m (99mTc) labeled autologous RBCs and by the presence of Howell Jolly bodies in the peripheral smear. Laboratory and clinical predictors of splenic dysfunction were assessed by multiple logistic regression. Results: We evaluated 66 children with SCD with a mean (SD) age of 7.41 (3.3) years. Impaired and absent splenic function as assessed by 99mTc scintigraphy was found in 13 (19.7%), and 3 (4.6%) children, respectively. Howell Jolly bodies in peripheral smear were found in 5 (7.5%) children; 3 of them had abnormal uptake on scintigraphy; all five had splenomegaly. Age > 5 years, > 4 episodes of vaso-occlusive crisis (VOC), > 3 hospitalization events in the past, > 5 blood transfusions, children not receiving hydroxyurea, reticulocyte count > 4%, and HbS > 70% were independent predictors of splenic dysfunction. Conclusion: The prevalence of splenic dysfunction in children with SCD in Central India is lower than that reported from the West. The decision to start antibiotic prophylaxis can be individualized in these children.en_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsNuclear Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsBiochemistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.citationJohns Juliet, Goel Anil Kumar, Jondhale Sunil, Venkatesan Dilip Kumar, Ravina Mudalsha, Shah Seema, Syal Simran . Splenic Dysfunction in Children With Sickle Cell Disease: A Single Centre Experience From Central India. Indian Pediatrics. 2024 Sep; 61(9): 817-822en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245719
dc.languageenen_US
dc.publisherThe Indian Academy of Pediatricsen_US
dc.relation.issuenumber9en_US
dc.relation.volume61en_US
dc.source.urihttps://indianpediatrics.net/sep2024/817.pdfen_US
dc.subjectHowell Jolly bodiesen_US
dc.subjectPneumococcusen_US
dc.subjectSpleenen_US
dc.subjectSplenectomyen_US
dc.subjectSickle cell diseaseen_US
dc.titleSplenic Dysfunction in Children With Sickle Cell Disease: A Single Centre Experience From Central Indiaen_US
dc.typeJournal Articleen_US
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