Synthesis, Evaluation and in silico studies of 1,8-Naphthyridine derivatives against antimicrobial activity.
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Date
2015-07
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Abstract
In present studies a series of novel 1,8-Naphthyridine derivatives (3a-3f) have been synthesized using nalidixic
acid as a starting material. The structures of the compounds were supported by FT-IR, 1H NMR and Mass
spectral data. All the synthesized compounds have been evaluated in vitro for their antibacterial activities against
several strains of microbes using agar dilution method. The synthesized compounds had moderate to good
antibacterial activity. Molecular docking studies reveal that 1,8-Naphthyridine scaffold shared structural
complimentary with DNA Gyrase B. Further, TOPKAT analysis on Ames mutagenicity model had shown that
this class of compounds have least probability of showing toxicity on experimental animal models.
Description
Keywords
1,8-Naphthyridine, Nalidixic acid, Antimicrobial activity, Ames mutagenicity, Molecular docking, QSTR, Structure based design
Citation
Sachdeva Sakshi, Bhatia Sonam, Mittal Amit, Sinha Manish. Synthesis, Evaluation and in silico studies of 1,8-Naphthyridine derivatives against antimicrobial activity. Journal of Applied Pharmaceutical Science. 2015 July; 5(7): 53-59.