Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement
Date
2022-12
Journal Title
Journal ISSN
Volume Title
Publisher
Cardiological Society of India
Abstract
Patients who undergo heart valve replacements with mechanical valves need to take Vitamin K Antagonists (VKA) drugs (Warfarin, Nicoumalone) which has got a very narrow therapeutic range and needs very close monitoring using PT-INR. Accessibility to physicians to titrate drugs doses is a major problem in low-middle income countries (LMIC) like India. Our work was aimed at predicting the maintenance dosage of these drugs, using the de-identified medical data collected from patients attending an INR Clinic in South India. We used artificial intelligence (AI) - machine learning to develop the algorithm. A Support Vector Machine (SVM) regression model was built to predict the maintenance dosage of warfarin, who have stable INR values between 2.0 and 4.0. We developed a simple user friendly android mobile application for patients to use the algorithm to predict the doses. The algorithm generated drug doses in 1100 patients were compared to cardiologist prescribed doses and found to have an excellent correlation.
Description
Keywords
Cardiac valve replacement, Mechanical heart valve, Atrial fibrillation, Vitamin K Antagonists (VKA), Prothrombin time, International normalised ratio (PT-INR), Warfarin, Support vector machine (SVM) regression, algorithm, Artificial intelligence, Machine learning
Citation
Amruthlal M., Devika S., Krishnan Vignesh, Suhail P.A. Ameer, Menon Aravind K., Thomas Alan, Thomas Manu, Sanjay G., Kanth L.R. Lakshmi, Jeemon P., Jose Jimmy, Harikrishnan S.. Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement. Indian Heart Journal. 2022 Dec; 74(6): 469-473