Effect of melatonin on glucose tolerance and blood glucose circadian rhythm in rabbits.

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dc.contributor.authorDhar, Men_US
dc.contributor.authorDayal, S Sen_US
dc.contributor.authorRamesh Babu, C Sen_US
dc.contributor.authorArora, S Ren_US
dc.date.accessioned1983-04-01en_US
dc.date.accessioned2009-06-01T07:40:54Z
dc.date.available1983-04-01en_US
dc.date.available2009-06-01T07:40:54Z
dc.date.issued1983-04-01en_US
dc.description.abstractExperimental studies on pinealectomized animals and in vitro studies using pancreatic tissue, have indicated that the pineal gland has a suppressive effect on the pancreatic B cells which secrete insulin. In this study, melatonin, was injected into rabbits and a statistically significant decrease in glucose tolerance was noted. The effect of melatonin in influencing the circadian rhythm of blood glucose was also studied in rabbits. Results showed that melatonin influences the circadian rhythm leading to a shift in the occurrence of minimum levels from 16.00 hr to 04.00 hr (next day) during fasting and from 16.00 hr to 20.00 hr during feeding. Also melatonin treatment lead to a statistically significant rise in blood glucose levels. It is probable that melatonin administration reduces glucose tolerance and influences the blood glucose circadian rhythm mainly through its effects on insulin release by pancreatic B cells.en_US
dc.identifier.citationDhar M, Dayal SS, Ramesh Babu CS, Arora SR. Effect of melatonin on glucose tolerance and blood glucose circadian rhythm in rabbits. Indian Journal of Physiology and Pharmacology. 1983 Apr-Jun; 27(2): 109-17en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108340
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --metabolismen_US
dc.subject.meshCircadian Rhythm --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucose Tolerance Testen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin --pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTime Factorsen_US
dc.titleEffect of melatonin on glucose tolerance and blood glucose circadian rhythm in rabbits.en_US
dc.typeJournal Articleen_US
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