Ketogenic diet in indian children with uncontrolled epilepsy.
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Date
2009-08
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Abstract
Objective: To evaluate the efficacy of the ketogenic diet in Indian children with uncontrolled epilepsy.
Study Design: Prospective observational study.
Setting: Hospital based.
Patients: 105 children (age 4 months to 18 years) with uncontrolled epilepsy enrolled in the ketogenic diet program over a period of 9 years and followed up for 25.7 ± 20.3 months (median:17 months) on the ketogenic diet.
Main outcome measures: Reduction in seizure frequency and comparison of improvement in two main groups of epilepsies, namely epileptic encephalopathies and localization related epilepsies.
Results: Thirty seven (35%) out of 105 children dropped out of the study and 68 remained on the diet. Thirty nine (37%) achieved 100% control, 23 (22%) achieved between 90 and 99% control, 7 (6.8%) achieved between 75 and 90% control, and 16 (15.2%) achieved between 50 and 75% control. Twenty (19%) achieved less than 50% control. Epileptic encephalopathies had a better response than localization related epilepsies.
Conclusion: The Indian version of ketogenic diet used is well tolerated and efficacious in controlling difficult-to-control epilepsy in children. Epileptic encephalopathies respond better than localization related epilepsies
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Keywords
Children, Ketogenic diet, India, Treatment, Uncontrolled Epilepsy
Citation
Nathan J K, Purandare A S, Parekh Z B, Manohar H V. Ketogenic diet in indian children with uncontrolled epilepsy. Indian Pediatrics. 2009 Aug; 46(8): 669-673.