Chemotherapy trial in paucibacillary leprosy using clofazimine.

Simple item page
dc.contributor.authorKatoch, Ken_US
dc.contributor.authorNatarajan, Men_US
dc.contributor.authorKatoch, V Men_US
dc.contributor.authorSingh, H Ben_US
dc.contributor.authorBhatia, A Sen_US
dc.date.accessioned1999-07-08en_US
dc.date.accessioned2009-05-28T10:15:49Z
dc.date.available1999-07-08en_US
dc.date.available2009-05-28T10:15:49Z
dc.date.issued1999-07-08en_US
dc.description.abstractIn a double blind study, 300 PB patients (smear negative, indeterminate, tuberculoid and borderline tuberculoid) were randomly allotted to two regimens, the control subjects (150 patients) receiving the standard WHO multidrug regimen of six doses of once a month rifampicin with daily dapsone therapy for six months, while the study group (150 patients) receiving 50 mg of clofazimine daily for six months in addition to the WHO regimen. After stoppage of therapy all the patients were followed up on placebo. The regimens were well tolerated. In 7.5% of patients on clofazimine containing regimen, the lesions showed persisting activity at the time of stoppage of therapy, compared with 16% on the control regimen. This activity subsided spontaneously, more rapidly, in the study group (80% compared with 30% in the control group) in six months. Two patients in the control group and one patient in the study group developed late reaction. There were no relapses in the study group, whereas, two patients have relapsed in the control group during a follow-up of 2.5 to 3.5 years.en_US
dc.description.affiliationCentral JALMA Institute for Leprosy, Taj Ganj, Agra.en_US
dc.identifier.citationKatoch K, Natarajan M, Katoch VM, Singh HB, Bhatia AS. Chemotherapy trial in paucibacillary leprosy using clofazimine. Indian Journal of Leprosy. 1999 Jul-Sep; 71(3): 311-24en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55080
dc.language.isoengen_US
dc.subject.meshClofazimine --therapeutic useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprostatic Agents --therapeutic useen_US
dc.subject.meshLeprosy, Borderline --drug therapyen_US
dc.subject.meshLeprosy, Tuberculoid --drug therapyen_US
dc.subject.meshMaleen_US
dc.titleChemotherapy trial in paucibacillary leprosy using clofazimine.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Leprosy