Geographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric study

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dc.contributor.authorRao, Cen_US
dc.contributor.authorKaur, Hen_US
dc.contributor.authorGupta, Nen_US
dc.contributor.authorSabeena, SPen_US
dc.contributor.authorAmbica, Ren_US
dc.contributor.authorJain, Aen_US
dc.contributor.authorYadav, Aen_US
dc.contributor.authorDwibedi, Ben_US
dc.contributor.authorMalhotra, Ben_US
dc.contributor.authorKakru, DKen_US
dc.contributor.authorBiswas, Den_US
dc.contributor.authorSavargaonkar, Den_US
dc.contributor.authorGanesan, Men_US
dc.contributor.authorSabat, Jen_US
dc.contributor.authorDhingra, Ken_US
dc.contributor.authorLalitha, Sen_US
dc.contributor.authorValecha, Nen_US
dc.contributor.authorMadhavilatha, Pen_US
dc.contributor.authorBarde, PVen_US
dc.contributor.authorJoshi, PDen_US
dc.contributor.authorSharma, Pen_US
dc.contributor.authorGupta, Ren_US
dc.contributor.authorRatho, R Ken_US
dc.contributor.authorSidhu, Sen_US
dc.contributor.authorShrivastava, SSen_US
dc.contributor.authorDutta, Sen_US
dc.contributor.authorShantala, G Ben_US
dc.contributor.authorImtiaz, Sen_US
dc.contributor.authorSethi, Sen_US
dc.contributor.authorKalawat, Uen_US
dc.contributor.authorVijayachari, Pen_US
dc.contributor.authorRaj, Ven_US
dc.contributor.authorVijay, Nen_US
dc.contributor.authorBorkakoty, Ben_US
dc.contributor.authorBarua, Pen_US
dc.contributor.authorMajumdar, Ten_US
dc.contributor.authorArunkumar, Gen_US
dc.date.accessioned2020-04-10T01:42:21Z
dc.date.available2020-04-10T01:42:21Z
dc.date.issued2019-04
dc.description.abstractBackground & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.en_US
dc.identifier.affiliationsManipal Centre for Virus Research, Manipal Academy of Higher Education (Deemed to be University), Manipal, Indiaen_US
dc.identifier.affiliationsIndian Council of Medical Research, Department of Health Research, Ministry of Health & Family Welfare, Government of India, Bengaluru, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Bangalore Medical College and Research Institute, Bengaluru, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, King George's Medical University, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, All India Institute of Medical Sciences, Bhopal, Indiaen_US
dc.identifier.affiliationsICMR-Regional Medical Research Centre, Bhubaneshwar, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Sawai Man Singh Medical College and Attached Hospitals, Jaipur, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Indiaen_US
dc.identifier.affiliationsICMR-National Institute of Malaria Research, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Government Theni Medical College, Theni, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Government Medical College, Amritsar, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Indiaen_US
dc.identifier.affiliationsNational Institute for Research in Tribal Health, Jabalpur, Indiaen_US
dc.identifier.affiliationsICMR-National Institute of Cholera & Enteric Diseases, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsICMR-Regional Medical Research Centre, Port Blair, Indiaen_US
dc.identifier.affiliationsICMR-Regional Medical Research Centre, North East Region, Dibrugarh, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Jorhat Medical College, Jorhat, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Agartala Government Medical College, Agartala, Indiaen_US
dc.identifier.citationRao C, Kaur H, Gupta N, Sabeena SP, Ambica R, Jain A, Yadav A, Dwibedi B, Malhotra B, Kakru DK, Biswas D, Savargaonkar D, Ganesan M, Sabat J, Dhingra K, Lalitha S, Valecha N, Madhavilatha P, Barde PV, Joshi PD, Sharma P, Gupta R, Ratho R K, Sidhu S, Shrivastava SS, Dutta S, Shantala G B, Imtiaz S, Sethi S, Kalawat U, Vijayachari P, Raj V, Vijay N, Borkakoty B, Barua P, Majumdar T, Arunkumar G. Geographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric study. Indian Journal of Medical Research. 2019 Apr; 149(4): 548-553en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195852
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber4en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_916_18en_US
dc.subjectDengueen_US
dc.subjectgeographic variationen_US
dc.subjectIndiaen_US
dc.subjectprimaryen_US
dc.subjectsecondaryen_US
dc.subjectviral research and diagnostic laboratoriesen_US
dc.titleGeographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric studyen_US
dc.typeJournal Articleen_US
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