Effect on curcumin on cholesterol gall-stone induction in mice.

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dc.contributor.authorHussain, M Sen_US
dc.contributor.authorChandrasekhara, Nen_US
dc.date.accessioned1992-10-01en_US
dc.date.accessioned2009-05-27T06:55:11Z
dc.date.available1992-10-01en_US
dc.date.available2009-05-27T06:55:11Z
dc.date.issued1992-10-01en_US
dc.description.abstractA study was carried out on the efficacy of curcumin in reducing the incidence of cholesterol gall-stones (CGS), induced by feeding a lithogenic diet in young male mice. Feeding a lithogenic diet supplemented with 0.5 per cent curcumin for 10 wk reduced the incidence of gall-stone formation to 26 per cent, as compared to 100 per cent incidence in the group fed with lithogenic diet alone. Biliary cholesterol concentration was also significantly reduced by curcumin feeding. The lithogenic index which was 1.09 in the cholesterol fed group was reduced to 0.43 in the 0.5 per cent curcumin supplemented group. Further, the cholesterol: phospholipid (C/PL) ratio of bile was also reduced significantly when 0.5 per cent curcumin supplemented diet was fed. A dose-response study with 0.2, 0.5 and 1.0 per cent curcumin supplemented lithogenic diets showed that 0.5 per cent curcumin was more effective than a diet with 0.2 or 1 per cent curcumin.en_US
dc.description.affiliationDepartment of Food Chemistry, Central Food Technological Research Institute, Mysore.en_US
dc.identifier.citationHussain MS, Chandrasekhara N. Effect on curcumin on cholesterol gall-stone induction in mice. Indian Journal of Medical Research. 1992 Oct; 96(): 288-91en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/18507
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholelithiasis --etiologyen_US
dc.subject.meshCholesterol --administration & dosageen_US
dc.subject.meshCurcumin --administration & dosageen_US
dc.subject.meshDieten_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.titleEffect on curcumin on cholesterol gall-stone induction in mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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