Classification of children as slow or rapid acetylators based on concentrations of isoniazid in saliva following oral administration of body-weight and surface-area-related dosages of the drug.

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dc.contributor.authorSarma, G Ren_US
dc.contributor.authorKailasam, Sen_US
dc.contributor.authorDatta, Men_US
dc.contributor.authorLoganathan, G Ken_US
dc.contributor.authorRahman, Fen_US
dc.contributor.authorNarayana, A Sen_US
dc.date.accessioned1990-02-01en_US
dc.date.accessioned2009-05-27T05:15:01Z
dc.date.available1990-02-01en_US
dc.date.available2009-05-27T05:15:01Z
dc.date.issued1990-02-01en_US
dc.description.abstractThe acetylator phenotype of 180 children aged 3-11 years was determined on the basis of isoniazid concentrations in saliva collected at 5 hours after oral administration of body-weight and surface-area-related dosages of the drug in a syrup form. Isoniazid 2.5 mg/kg was administered on one occasion and 75 mg/m2 surface-area on another, with an interval of 3 days between the occasions. A cross-over design was employed and the sequence was determined by random allocation. The distribution of the concentrations was bimodal with both procedures, indicating the presence of two groups namely, the slow and rapid acetylators. The criterion for a rapid acetylator was a concentration of 0.3 micrograms/ml or less by body-weight-related dosage and 0.4 micrograms/ml or less by that based on surface-area. Based on these criteria, 62% of the children were classified as slow acetylators and 38% as rapid acetylators by body-weight, and 59 and 41%, respectively by surface-area, and the findings were similar in children in the different age-groups. The agreement between the two procedures was 98%.en_US
dc.description.affiliationTuberculosis Research Centre, Indian Council of Medical Research, Madras.en_US
dc.identifier.citationSarma GR, Kailasam S, Datta M, Loganathan GK, Rahman F, Narayana AS. Classification of children as slow or rapid acetylators based on concentrations of isoniazid in saliva following oral administration of body-weight and surface-area-related dosages of the drug. Indian Pediatrics. 1990 Feb; 27(2): 134-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/9457
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAcetylationen_US
dc.subject.meshAcetyltransferases --geneticsen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshBody Surface Areaen_US
dc.subject.meshBody Weighten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoniazid --administration & dosageen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshSaliva --analysisen_US
dc.titleClassification of children as slow or rapid acetylators based on concentrations of isoniazid in saliva following oral administration of body-weight and surface-area-related dosages of the drug.en_US
dc.typeJournal Articleen_US
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