An evaluation of cold chain in Maharashtra & Karnataka states by potency testing of field samples of oral poliovirus vaccine.

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dc.contributor.authorDeshpande, J Men_US
dc.contributor.authorRao, V Ken_US
dc.contributor.authorNadkarni, S Sen_US
dc.contributor.authorBhatia, J Pen_US
dc.contributor.authorRodrigues, J Jen_US
dc.date.accessioned1995-08-01en_US
dc.date.accessioned2009-05-27T08:27:31Z
dc.date.available1995-08-01en_US
dc.date.available2009-05-27T08:27:31Z
dc.date.issued1995-08-01en_US
dc.description.abstractThe cold chain for oral poliovirus vaccine was monitored in Maharashtra and Karnataka by potency testing of vaccine vials collected from various stages of the delivery system. Results showed that cold chain maintenance improved in the state of Maharashtra within a period of three years as the monitoring began in 1987. Of the 6289 samples of trivalent OPV collected from all 30 districts of the state during 1990 to 1992, 5834 (92.8%) had retained virus titre of at least 10(5.81) TCID50/dose. In comparison, 72 per cent of the 1660 samples collected from the state of Karnataka during the same period were found to contain this minimum required virus titre. Defects in cold chain maintenance in Karnataka could be demonstrated by plotting virus titre of samples of individual batches collected from different outlets. It was concluded that potency retesting of OPV samples for cold chain monitoring will ensure proper storage, transport and use of potent vaccine in the field.en_US
dc.description.affiliationEnterovirus Research Centre, Bombay.en_US
dc.identifier.citationDeshpande JM, Rao VK, Nadkarni SS, Bhatia JP, Rodrigues JJ. An evaluation of cold chain in Maharashtra & Karnataka states by potency testing of field samples of oral poliovirus vaccine. Indian Journal of Medical Research. 1995 Aug; 102(): 60-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24517
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshCryopreservationen_US
dc.subject.meshDrug Monitoring --methodsen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshIndiaen_US
dc.subject.meshPoliovirus Vaccine, Inactivateden_US
dc.subject.meshQuality Assurance, Health Careen_US
dc.subject.meshRefrigerationen_US
dc.subject.meshTime Factorsen_US
dc.titleAn evaluation of cold chain in Maharashtra & Karnataka states by potency testing of field samples of oral poliovirus vaccine.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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