Fluconazole in the management of neonatal systemic candidiasis.

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Date
1996-10-01
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Abstract
OBJECTIVE: To evaluate the role of Fluconazole in the management of neonatal systemic candidiasis. DESIGN: Descriptive, retrospective analysis. SUBJECTS: 23 neonates diagnosed as systemic candidiasis based on clinical suspicion with blood and/or urine culture positive for candida were treated with Fluconazole (5 mg/kg/day) for > 7 days. RESULTS: Babies had mean birth weight 1590 + 533 g, mean gestation 32.3 + 3.1 wks and fungal sepsis was diagnosed at a mean age of 14.3 + 7.9 days. Candida albicans (43.5%), C. tropicalis (21.7%), C. guillermondii (13%), C. parapsillosis (13%) and C. krusei (8.7%) were the species isolated. Fluconazole was effective in 82.3% cases with no side effects. Four resistant cases were C. parapsillosis (n = 2), C. albicans (n = 1) and C. guillermondii (n = 1) and there were three deaths, all in resistant cases though one death was unrelated to candidemia. CONCLUSION: Fluconazole is a safe and effective drug for neonatal systemic candidiasis.
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Narang A, Agrawal P, Chakraborti A, Kumar P. Fluconazole in the management of neonatal systemic candidiasis. Indian Pediatrics. 1996 Oct; 33(10): 823-6
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https://imsear.searo.who.int/handle/123456789/10880
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Indian Pediatrics