Meningiomas – transition from traditional histological grading to molecular profiling in WHO CNS5: A Review

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dc.contributor.authorGoyal-Honavar, Aen_US
dc.contributor.authorJayachandran, Ren_US
dc.contributor.authorChacko, G.en_US
dc.date.accessioned2023-08-10T07:32:34Z
dc.date.available2023-08-10T07:32:34Z
dc.date.issued2022-05
dc.description.abstractDespite being the most common primary intracranial tumor, meningiomas are classified largely based on histological features. The current system of grading has been shown to be unsatisfactory due to its poor reproducibility as well as the considerable variability within grades. With the increasing availability of genomic and epigenomic profiling, several markers have been suggested to correlate with the location, histological subtype, and clinical behavior of meningiomas. These developments have enabled the development of targeted therapy, as well as individualized use of currently available adjuvant methods. These include copy number alterations (CNAs), specific genetic abnormalities (germline and sporadic), and genome-wide methylation profiles. In this review, we recapitulate the changes in the classification of meningiomas thus far, discuss the various histological subtypes recognized, and present the available literature on the genetic and epigenetic profiles of meningiomas. The recognition and further study of these markers have the potential to usher in an era of personalized therapy in the management of meningiomas, vastly improving outcomes as has been observed in the case of several other tumors.en_US
dc.identifier.affiliationsDepartment of Neurosurgery, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.citationGoyal-Honavar A, Jayachandran R, Chacko G.. Meningiomas – transition from traditional histological grading to molecular profiling in WHO CNS5: A Review. Indian Journal of Pathology & Microbiology. 2022 May; 65(1): 83-93en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223269
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_1085_21en_US
dc.subjectClassificationen_US
dc.subjecthistologicalen_US
dc.subjectmeningiomaen_US
dc.subjectmolecularen_US
dc.subjectreviewen_US
dc.titleMeningiomas – transition from traditional histological grading to molecular profiling in WHO CNS5: A Reviewen_US
dc.typeJournal Articleen_US
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